Appendix V Findings of Ep demiological Studies of Cancer in Irradiated Populations (From J. Shapiro, Radiazion Protection, pp. 260-4, Harvard U. Press, Cambridge, MA, 1972) No ot caves Subject of study |. Haroshima and Nagasaki A-vomb survivors (bomb exploded 1945). Bnil et ai.. 1962 (81) Follow-up tme (yrt §-43 2. Hiroshima and Nagasaki A-bombd survivors (women) Wanebo etal.. 1968 (238) V3-24 3. Hiroshima and Nagasaki A-bomb survivors exposed prenatally Jabion and Kato. 1970 (93) 10 4 Japanese A-bomb survivors ¢x posed within 1400 m of detonation tdied 1950-1962). Angevine and Jabion. 17 § Children exposed prenatally due to abdominal x-ray to mother (exposed 1945-19S6 and died before end of 19581. Court Brown et Dose (R o¢ rads) 0-20 21-80 81-320 No. of persons” Form of cancer 85,070 13.184 % 695 o-4 10-39 40-89 90-199 >200 Unknown Unexposed vontrot >64,500 person-rads” Observed Expected In exposed group? if noe exposed® 21 6 4 19) 30 20 3 s 2 s o 2 2 73 3 2 2 23 2.3 61 | 075 Leukemia Leukema Leukemia 3.082 1.262 87 302 841 x30 2.458 Breast Breast Breast Breast Breast Breast Breast cancer cancer cancer cancer cancer cancer cancer 1.292 All cancers 1.218 All cancers. autopues except leukemia at $6.8 e 10s 1964 (95) at 349 166 Leukemia All cancers ai., 1960 ( 239) 6. Children exposed prenataily (born in 1947-1954 and died betore end of 1960) MacMahon. 1462 (240) 7 Infants who recerved irsadistion of chest before age 6 mo. in treatment for enlarged thymus(treated 1926-1957, follow-up in 1963) 4-13 tee 77 000° 13-36 61-600 Lower dose [Thyroid group Tayrow (bemgnt 2.207 Leukemu €22,226 per- Hempeimann et al., 19> (160) ws 60 4 6 3 107 xO pas 14 1S 3 06 60 aad 0 0 90. Qus son yr al risk i Higher Jose group 498 Thyroid Thyroid (benign) Leukemia 11E 48S per- son yrat tink? 3 infants wradsated rouunely with X-fays to antenor mediastinuT through small (4X 4 cm) port. 7 days after bisth, as “apparently harmless and perhaps beneficial procedure”(x-ray 1938-46. fol- low-up 1956-58). Conte et al.. 1900 (146) 9. Children treateg with x-rays to head, neck, of chest for various benign conditions, mainly ““en- large” thymas and adenitis, 10-20 78-880 mostly 150 . 14a1, inchuding 144 with enlarged thymus >t <S0 14%) (KIT $0200 C26) 200-600 ¢33'7) hott Upto 23 3,872 Thyroid careinoms Leukerma Thyrow Thyra (benign ul 7 0 a ~ treated before age 16 and followed till age 23. Saenger et al., 1960 (202) 10. Children treated before age 16 with x-rays for entarged thymus. pertussis, and head and neck diseases: and died before age 23 (treated 1930-1946; followup 1940-1956). Mueray et Not grven ab. 1959 (241) - 134 - Leukemia 7 i4