-j= Oz radioiodine tnerapy is to know srecisely the rac dose that was reeivec zy, the gianc. The important = 425tion is whether there is 4 just elevate dbse oz -"+I wrecn will bring a hyperthyroid satient to a euthyroid State «itnout) uitiretealy developing hypothyroid-==.. The cther question is whether ar iraces te aose o -°--l is more inclined t= lead to nectlasm formation. In 4 few cases, Mistslogic samples cf the gland have Leccome av llazle secause surgery was indicated owing to the appearance of a mass or persist 2 or syperthyidism that required =satment. The procurement or tissue i= srov ing =0. sppor“umity to study the effects of the radiation in various arezs <f glané sy autoraclography. Thus, we continue <> follow cur radioiodine therapy cass= dili entiy witn re- peated examinations tc i50k for the devélopment of masses anc <9 re ppraise thyroid €. M function. The Protiem of Selecting the Right Dose of Treatment of Graves’ Disease An a dose of radiated. 7 *"*2 fort rtant variéi=le in trying to anticipate and estima es th 1211 is the s-ructural character of the particular zland This is pre=Sebly as important as the weight or sics of all of the volume may mst be attributable to thyroid cells - _rAisto roids of Graves' disease may be quite variable. The gland ==; trated with lymphocytes, in which case, it will be very five and A considerable part of its volume may be blood and as a result it effectiveness of tis to be ir e gland because gicaliy the thyensively infil- bery cm examinatio: ill be very soft, compressible and have = bruit. The gland may be involuted wich a volume occupied by colisid. Such a gland is rather firm, bu= not tensively infiltrated with lympocytes. This gland often feels ra very hyperplastic glar<c with few lymphocytes or colloid is composed ds firm as when expedsly. The of reiatively more of gland usually occirs in younger individuals. gntrins-cs character- cells. Such a gland is quite vascular. The history is of scort diratian. We believe <hese This type istics of the gland <= Graves' disease play a major part ir. the effectiveness of the radiation. The greater the space occupied by lymphocytes, x=-_loidj tissue the more ionize=ion is spent in these structures rater t or connective in the cells that produce hormone. Such characteristics can only be inferrec =rom afimowlecge of the pathology as it relates to the features of the physical exac=mati Unfortunately a biopsy of a large number of thyroids before it therapy is z¢ven not justifiable. However, any physician or surgeon who devotes a great deal <== his thyroids, judges and records the character or the giand at poysl personally reviews the nistology on each gland that is oper=ced si relate the findings wich reasonable accuracy. Information = the ter of the gland, alcmz with kinetic data on the behavior cr the given individual shou. help unravel the explanation as to y th kime te examining examination and the dose oF +311 pro- duces prompt hypothyrciaism in some patients and is relative_y in rfective in others. In a similar manner tre surgeon .whc records his estimate oz ne w Graves' disease from is preoperative physical examination =.3 th amount of tissue he resoves and from that estimates the amo=t of has performed a unique control on his preoperative estimate. Wit refine his judgement c= thyroid weights for those to be trezced wi ight of a thyroid ir sees and weighs ti tissue “nat remains e th rience, he can 2