30 ° rn a 2.70 T 100 © EXPOSED ® UNEXPOSED & COMBINED WITH STANODARO ERROR MEANS 180.4447 &* y® 12,24 + 0.671 « tok 20}- 3 TT @ UNEXPOSED o EXPOSED 180,390: * * 90-- ] 6 COMBINED TT T7379 e | y* 23.830 + 0.9234 x 80}- Te 2.31 50 233 40 | l2 TO l 30 pot 40 50 60 AGE l 80 70 T 90 t 13 30 PERCENT AGING T T | ° EXPOSED ® UNEXPOSED ° COMBINED WITH STANDARD ERROR MEANS 7 r= 0.99 %* y* 0.51#0.381 +0.0t 0? = . 60 4 50 = a 40 | 30h * COEFFICIENT FIR AGE CORRELATION uF EACH CRITERION USEG TO WEIGHT SCORES BEFORE SUMMING I * *® CORRELATION WITH AGE SIGNIFICANT AT 1% LEVEL j 30 } 40 ! 50 60 AGE 70 # ® CORRELATION WITH AGE | BO Figure 48. Biological age scores. 3 | SIGNIFICANT AT 1% LEVEL Po 30 40 50 60 AGE 70 80 930 Figure 47. Cholesterol (1957). ] 1 COMBINED WEIGHTED DATA * 80 FTOL T | ioe 2 Figure 46. Potassium, males (1961 and 1965). 100 ~“ 160 20 90 * * CORRELATION WITH AGE SIGNIFICANT AT 1% LEVEL 20 10, 1.52 80 }~ 00 | 30-— 4 mg PERCENT 60 PERCENT ri g/kg BODY WEIGHT PERCENT 70 } 90 _ at an earlier time than it would ordinarily be manifest. One aspect of this phenomenon maybe related to rapidity ofcell proliferation (generation cycle) in a particular tissue, i.e., with more rapidly proliferating cells of the bone marrow, leukemia occurs relatively soon after irradiation, while malignantlesions of the skin would not become manifest until later in this more slowly proliferating tissue. In the Marshallese the high incidence of adenomatoid goiter in the morerapidly pro- liferating thyroid glandsof the children may pos- sibly represent premature appearance oflesions which are knownto occurlaterin life and thus in a sense represent an aging process. On the other hand, the fact that no tumors (except benign nevi) have been noted in the heavily irradiated skin of these people might indicate a longer induction period dueto slowercell * urnover of the skin. In considering futur< aging studies in the Marshallese it is hoped t iat more sensitive tests of vigor and organ function suitable to the conditions of study may be used. However, it must be borne in mind that such subtle aging effects may not become detectable by ordinary clinical means