CONTENTS Surgical Cases......c.scsccccsssesssssssssssessssesncsarsenseesesssnsenssceseensversessanenssrecsucnnscescenscaurassenaasssssssyestes Gross Appearance..........cscsssssessssssessssssessecsesescsrssassessssnensssesisnscceseeanecereaneeenenantuassnseaeenserass tess 31 Microscopic Appearance........sscscssseereressersersensenesssesneesssnseessssanenesnesanettensennenacenensconesensens Thyroid Function Tests Related to Thyroid Abnormalities and Growth Retardation........ 33 Results of Thyroid Hormone Therapy.........::.cc:cecscssessseecneeeacseesnesnearsnensseeneansavesseseneeceneenee ens 40 Discussion of Thyroid Findings. .........ccccccccssssesssee caseenes senenersensestsaeesene cee steeceaeesseaenecesenenanans Aging Studies........ecccccccseeesssssessssessssssesssssssecesesesseesccssecnnseessacsnecenssneenssenetaessestaraneteeseneenasnaenenttd 40 Methods... ccscccecsssescsesscscsescsssesscssesenesseesesscsedensscesesusssenenesssegsenesssassensaneneneaenersgnecseessederessueveneses 43 Tmtegumentt........ ee eccsceceeesecsesessnesssesssseessenseaseenecnccancasensensensenenentseganeuscauestieceacenenateseaeeaennety 43 Special Senses.........sscccscccsssssessessseeesesceessenesnessesesseeseenteenesnnesnessseessessusssanaessceasanseaessueeasersacs 31 33 43 44 Cardiovascular Changes............cccccccesscssssssseseesesssnsesesseacseseensseceenassoeseseteneseaeneneanesgeansneasees 44 Neurological and Neuromuscular Function...........ccccccccsseccseesesesessseeseesssenssenscenaneneeneers 44 Miscellaneous Tests............:ccccccseeceressssssees saseeseescsassnscnenesessesesesenessssessensecassssessensceeseeneneenaens 45 Correlation of Data..........0..cc:ccccccscsesscsenesssacneersessnssessesessssessecseesassaseeasees seenesasasaseecneetenseers 45 Results of Aging Studies..0.0...0..cc. ccc ccescsassesessecesessneeeesensseensnsseseceenenesesseanssaestenerencaaseneecens 46 Discussion of Aging Studies......0.0....ccsessssssssessessessecessesseeesesassesseesssasseceneessacaeesssneecseneenecneatts 46 Hematological Studies... cece cee cesseeeesceseceneee cnssseseseesssansaseceeeesseesesseaeeesgenseesesnes ease cnenenenes 51 Rongelap Population... cece sseseseeneeeesrenenssearensseaseesenseseessenseassessaeetnescnssaneeeens 51 Ailingnae Population... ccccsessesesccecsesseesenee sensceasearnesecssestesseassesssessesesesseneesausesentnanites 54 Utirik Population.................. lees cbesseee credetenessensseeiesgenseededessageeteeseeaticaseneesscadis gee seadeasssesnseeanaess Children of Exposed Parents.......0.0.. cccccccsscsserssscsessseesenessessssnsesssseseeseassesssunessseneasseeaeeaenes 34 Leukemia Survey... ..0.....cccececscccsessessssseesescnsensserseesecsecssceveotenguseassencasoessecensueneesessnesseasaeassnessessees 55 Statistical Analysis of Rongelap Blood Data. uo... ccc ceseeseesseeeee case seeeeesecaeeseensseeneneraetees 55 Chromosome Studies... 0c ssesesecseesecssesssseesesesecsessaenscseesasseensesseesendcasedsen see sessaaseseavenseeaes 55 Other Laboratory Studies... esesssssscsseseessescesesseessesceee sessseseussssssessearesssesseessesscesseseeensras 57 Total Blood Volume and Red Cell Volume... ccccsccsesecsssesesesenessecseeseersnesseaeseeecasseenscaea 57 Test for Australia Antigen.....0......0....ccccesscsescsesesecsescesssccesccaeeerseseeeeasnecsseseneacaesseeesses seas saeeseestsas 58 Estimation of Internal Body Burdens of Radionuclides. ....0.0...... cece cs cceeerreneceecneesernentees 58 Whole-Body Counting... cceecciceseccsenteeene csnceeesenesecscasseseacnessnatestesqugsseeneeaseetanetientees 58 Radiochemical Analysis of Uri 1.0.0.0... cccccccctecsceseeceeeteeseesenecctsesseseeaeeaeetenesaeaetseussassesaceaseess 59 Results and Discussion of Body Burden Estimation......0..0...0....:c:cccccccsceceeeseeeceeceeee caer eeeeaeeetass 61 Comparison of '*’Cs Levels in Marshallese and Alaskan Eskimos........0...0:.00:cc:cceeeeee cones 63 Radiochemical Analysis of Coconut Crabs... ccessccecsescesceesseseeesesseaseseseerensstseecseneneess 63 55