TITLE Human Health Effects from Energy Generation: Medical Studies of the People of the Marshall Islands Accidentally Exnosed CONTRACTOR NAME Associated Universities, lnc. 20f. to Fallout BUDGET AND REPORTING CODE DATE PREPARED HA-02-01-01 CODE BNi WP NUMBER 03/31/80 TASK NO, REV. NO. 0 Technical Progress cont. Expected Progress in BY-2 (FY 1980) cont. During FY 1980 all research records are being reviewed and condensed for transfer to microfiche and finally for computerization. This process requires restructuring the charts in a problem-oriented format to provide the structure necessary for flexible clinical and research utilization in a computerized format. During the last two surveys of FY 1979 there was an obligation to examine and care for the people of Bikini. This endeavor greatly expanded the patient load without supplemental funding, and it is anticipated that continuation of these examinations will be required. Funding, responsibility, and authority for this activity has been under discussion at the Department of Interior and the Department gf Energy for a number of months but the problem remains unresolved. In addition, if the Likiep survey reveals an increased incidence of thyroid pathology, as is suspected, a medical survey of that island and possibly of Wotje, Alluk, and Mejit may be required. If these incremental increases occur, the study population would be more than tripled. Emphasis on health and radiation education will be continued and increased to place radiation in its proper perspective in a matrix of health risk for the Marshallese. Continued monitoring of all populations determined to be at increased risk from radiation-induced diseases will continue, focusing primarily on the thyroid, hematopoietic system, breast, lung, stomach, and colon using Suitable screening tests. Expected Progress in BY-l (FY 1981). In view of the serious late effects of fallout exposure, continued medical surveillance of the exposed populations is mandatory as the studies are still in the latent period of a number of significant carcinomas. Special examinations for the thyroid abnormalities, as well as for neoplasia of other organs and tissues and other late effects must be continued. In light of the recent renewal of interest of long term effects of "low level" radiation, the data from this study, even though the population is small, should serve as one of the longest prospective studies of the effects of both acute high level and long term low level external and internal radiation. Other studies to be pursued include: a) thyroid comparison studies--it is hoped that the Department of Energy funds will continue to be approved for carrying out thyroid surgery in the United States on unexposed Rongelap and Utirik people in the extended comparison study where such surgery is indicated; b) reevaluation of dosimetry of the Utirik people, including thyroid doses; c) study of the nature and the treatment of diabetes in Marshallese to include trace element analysis of the people and the echosystem; d) studies with Dr. Raymond A. Popp of Oak Ridge (for frequency of isolucine substitution in hemoglobin of Marshallese blood as. an index of somatic mutations associated with radiation exposure and aging; e) studies of polymorphism and rare protein variance in the blood cells of children of exposed and unexposed parents--Dr. James V. Neel at the University of Michigan has expanded his battery of tests for these variants and has agreed to continue these studies on Marshallese children; and f) ', A ~ { rahe - jp 1013223