IAEA-SM-L19/8 More recently several other children with lesser degrees vf retardatLlon of 4 odules of prowth had berun to shew sume dexree of In view of the seriousness of the above findings it was decided several years apo to give thyroid hormone therapy to the exposed people, The rationale for this therapy was to furnish normal levels of cxonenous thyroid hormone thereby repressing pituitary TSH levels and removing 969, ac reatviously the gland bren she und from stimulatien of that hormone, Effectiveness of treatment in regard to inhibition cf growth of nodules is difficult to evaluate in view of uncertainty of adherence to a strict treatment regimen in some of th: people. however the effect on growth and development of the body appears to be encouraging. The two boys who had snowed hypo- surgery. thyroidism and the greatest growth retardation showed definite enhancement. Fig. 5 shows the results of hormone treatment in these two boys on ELOPMENT development as evaulated by skeletal age. Fig. 6 shows the increased growth and improved appearance of one of these boys following hormone treatment. “~~ js 2 e Ee | — “— ei } q vr, wanes i a Te \ (i BS 7" « “x's i - # \ f Fa C _ = true pase i -lese | | Fee ey ted , about > Lact | No iger. 4] 4 4 c studies hildren, e arly .o were > thyroid deficiency prior to surgery, This was based on lowered thyroxine levels, inereased levels of TSH, reduced uptake of radioiodine and poor response to TSil stimulation, lar a 333 \ \ } I it. { 1 | | ’ . t \ Ro bs ne we = \; . BO + rofmone cherapy FiG.8. On left, boy with marked growth retardation and hypothyroidism before thyroid hormone treatment, and on right same boy 6 months after treatment narted. (No.3 in Fig.5). CPF snt in two