IAEA-SM-L19/8
More recently several other children with lesser degrees vf retardatLlon
of 4
odules
of
prowth had berun
to shew sume dexree of
In view of the seriousness of the above findings it was decided
several years apo to give thyroid hormone therapy to the exposed people,
The rationale for this therapy was to furnish normal levels of cxonenous
thyroid hormone thereby repressing pituitary TSH levels and removing
969,
ac
reatviously
the gland
bren
she
und
from stimulatien of
that
hormone,
Effectiveness
of
treatment
in regard to inhibition cf growth of nodules is difficult to evaluate
in view of uncertainty of adherence to a strict treatment regimen in
some of th: people. however the effect on growth and development of
the body appears to be encouraging. The two boys who had snowed hypo-
surgery.
thyroidism and the greatest growth retardation showed definite enhancement.
Fig. 5 shows the results of hormone treatment in these two boys on
ELOPMENT
development as evaulated by skeletal age. Fig. 6 shows the increased
growth and improved appearance of one of these boys following hormone
treatment.
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arly
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thyroid deficiency prior to
surgery,
This was based on lowered thyroxine levels, inereased levels
of TSH, reduced uptake of radioiodine and poor response to TSil stimulation,
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rofmone cherapy
FiG.8. On left, boy with marked growth retardation and hypothyroidism before thyroid hormone treatment, and on right same boy 6 months after treatment narted. (No.3 in Fig.5).
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snt in two