size exhibited 3 adenomatous nodules, 1 adenoma, 2 carcinomas, and 2 occult
papillary carcinomas, one of which may have been a follicular carcinoma.
Uncertainty was associated with diagnosis of follicular carcinoma, one in the
exposed group and one in the comparison group, because of equally divided
opinion among consulting pathologists.

However,

it was reasoned that both

follicular carcinomas could be excluded from a risk coefficient estimate without seriously biasing the results. Diagnoses on five other individuals are
pending. All five are from Utirik Atoll; three are in the <lO-year old age
group, and two are in the 10= to lL8-year-old age group.
METHODS
Adams et al. (6) classified thyroid abnormalities following a scheme
similar to that used by the World Health Organization and a committee of
pathologists who had special expertise in diseases of the thyroid (7).
The
following nomenclature was used:
Adenomatous nodule:
a focal proliferative lesion consisting of changes
typical of adenomatous goiter; the lesions do not fulfill criteria of true
neoplasms.

Adenoma:

an encapsulated proliferative lesion with a uniform internal

growth pattern and benign clinical course.
Occult papillary carcinoma:

a small nonencapsulated sclerosing carcinoma,

considered to be clinically benign even with positive regional Lymph
nodes.

Papillary carcinoma:
larger, infiltrating carcinoma, usually containing
both papillary and follicular components.
The smallest lesion diagnosed
as a papillary carcinoma, by the consultant pathologists, was 0.8 cm in
diameter.

The recent computation of thyroid absorbed dose was performed for inhabitants of Rongelap, Utirik, and Ailingnae Atolls who were exposed to fallout

on March 1, 1954.

The amount. of fallout activity taken into the body was

estimated from the value of
I excreted in urine obtained from 64 persons
who were at Rongelap. yee other components of fallout taken into the body,

particularly
position.

I and

I, had to be inferred from studies on fallout com-

The authors of the reassessment study made dose estimates on the

basis of actual BRAVO fallout composition.

The intake pathway and the time

post-detonation ac which intake was likely to have occurred were obtained from

interviews with the exposed people, and historical records and were factored
into the new dose estimates.

A detailed development of the dose reassessment

was reported by Lessard et al. (3).

The radioepidemiological tables assembled by the Working Group (8) represented the best scientific judgment for the assignment of cancer risk from
external radiation; thus we obtained one estimate of external exposure risk
coefficient from this source.
For persons less than 20 years of age, the
Working Group adopted an average risk coefficient of 3.3 excess cancers per
milifon person-rad-years at risk, and for persons 20 years or older they chose
a value of 1.0 excess cancer per million person-rad-years at risk.

minimum latent period was chosen for thyroid cancer.

A 10-year

The Working Group

calculated thyroid cancer risk based on a linear dose-response function and

maintained that the estimates of risk applied to external x and gamma irradiation, but not to the intake of radioisotopes of iodine.
The BEIR III (1) risk coefficients were based, in large part, on external

21

Select target paragraph3