T

1

T
T
o EXPOSED
® UNEXPOSED
& COMBINED WITH STANDARD
ERROR MEANS
r= 0.4447 **
y= 12.24 +0671 x

2.70

I

1901

30;—
|

T
@
o

T
UNEXPOSED
EXPOSED

T

379

qo COMBINED
.

r= 0.3901 * *
y= 23.830 + 0.5234 x

'

-

_

go

beta

100
20

** CORRELATION WITH AGE

SIGNIFICANT AT 1% LEVEL

|
30

|
40

50

'
60
AGE

|

to |
70
80
90

30

80 —

rol

]

TT

COMBINED WEIGHTED DATA *
© EXPOSED
® UNEXPOSED
Q COMBINED WITH STANDARD
ERROR MEANS

°

r= 0.99 **

|

4

eses es

=

oO

13

0

SIGNIFICANT AT | %EVEL

1
30

|
40

|
50

|
+60

AGE

a
70

1
80

|

Las
90

proliferating cells of the bone marrow, leukemia
occurs relatively soon after irradiation, while
malignant lesions of the skin would not become

manifest until later in this more slowly proliferat-

ing tissue. In the Marshallese the high incidence

of adenomatoid goiter in the more rapidly pro-

liferating thyroid glands of the children may possibly represent premature appearance oflesions

which are knownto occurlaterin life and thus in

3

m™m

* * CORRELATION WITH AGE

cycle) in a particulartissue, i.e., with more rapidly

>

y= 0.51+0.38 x +0.01 x?

* COEFFICIENT FOR AGE
CORRELATION OF EACH
CRITERION USED TO WEIGHT
SCORES BEFORE SUMMING

oO

°

°

|
+ '80
|

at an earlier time than it would ordinarily be
manifest. One aspect of this phenomenon maybe
related to rapidity ofcell proliferation (generation

a

mM
oO

PERCENT AGING

°

|
20
:

Figure 47. Cholesterol (1957).

T

60—

w

|

10h

e

Figure 46. Potassium, males (1961 and 1965).

190

1.52

mg PERCENT

3

305

PERCENT

PERCENT

g/kg BODY WEIGHT

2.3!

a sense represent an aging process. On the other
hand, the fact that no tumors (except benign nevi)
have been noted in the heavily irradiated skin of
these people might indicate a longer induction

period due to slowercell turnover of the skin.

In considering future aging studies in the

* * CORRELATION WITH AGE
SIGNIFICANT AT 1% LEVEL
i
30
40

!
50

60

AGE

|
70

{|
gO

Figure 48. Biological age scores.

dt
90

Marshallese it is hoped that more sensitive tests
of vigor and organ function suitable to the condi-

tions of study may be used. However, it must be
borne in mindthat such subtle aging effects may

not becomedetectable by ordinary clinical means

Select target paragraph3