:f Bn Ay tt Bee ae ceo abd Rte6 o weer ie RS ito bene SO beaters SAAR Ove 6 puoteiiy net together nrogress of planaed can de conipleted. cos et rehetons from ra abe ath Wingar extrapolation with no threshold. A plotting . . linear. Anotker wee OF the imensive study of ttoseTesponse Telatiens for radiorecent use of the 7 “dou Ming tos Scopcenn Tae wos develoored nuclides is 7 teat! ida stgmectd one. Tamplin & Gofmar the only one that fits the beagle-dog dats a difference between the alpha and beta or siatvsis Suggests. the direction is consistent tate recovery from effects of the two kinds “tons may be just as valid. to Bundleos gsembing the genetic effects oF radiation and /s specifically the dose regain. (2 dounle che ine dune cate of oo given mutauen. (NOTE: Sume other ge uu :'Teets may rise as the square of the dose or by other functions). The conce; 25. very dependent! upon the pattctiar kineties of the genetic response. esr. . car, cumulative. ete. Same author: (143, 151) have applied this -s differ with the model is seen in the analys’s concept ty core nogenesis induced by radionuclides as well as by external radia- 1000 rads the projected risk (in man) in 50 tion. Fur. arcental to the argument is whe:hsr or nat ‘increase in incidence is ~ -upads for a “low-dose linear model” and 1a dose squared model. Thus the differer.ce vred Rosenblatt (146, 147) utilizes a three. 4-40 account for simultaneous contribut ons 2 ancidence in beagles receiving radiury or « utler-Ederer life table method (143. for Baan atisoue. This logis ic type respe tse ats age-related incidences to be calculated in propor ut to normal iaciklence ries o7 on ar tsolute basis. While the data brows $ caar are prime’ dy tor extorael n.d. iga, an [CORP analysis (157) doesnot. wcagralsupper. setorre: siew. 7) akes considerable difference to the pre fon of risk froun the tovaily of veriecas forms of cancer induced by radior vcuits, Bla: (0 o nes used the dost oc. nectar nd Cen for radionuclides as a tool for im .c 2 generac meychan sm. ae front ceera studies €153, 154), the last ota as pe Pe nero se ie beagtes. “kin Heme OR ee rete sity redm. 7 f Stoers, Newman & Altschuler 9° “aan incidence would occur at age 50 in the (iSi3, a: lang cancer ie uparhaps at “af cone tumor in mouse and dogreceiving See outs, teurers a much bot or inn aun , kee is vie. ba cer case he Concindes that there long wath risk evaluations based on it, by peree a ke ber uy tedeton, One, char- Boe Pig crass do Gareet © fall Booey wgenebh. the ather, characteristic dee.and Folles¢ onlyafter a long ‘yg Square of the number of beta particles «Rody weight. This did not appear to hold, oy venerabzes that the data froet mouse. AUD fiero. Dic uses averaugiu -«elial dos from the ocvecal bone-seeking nuclides iy the dogs, applied betu-radiation dose in the rats, and the inferred lune @o 6 fy vaicuiation back frou messuicd 7'°Pb costed of bone in the soentaltly equal radiosensitivity of the critical ‘olsen: ts! ohenomenon. urnuat Ps ide, 5 oh Vie hb Yosutics Corstinii doxw-cale. wih is cerWV Or pot oa bs a besser a ba da Ovens Caturibg suuplificaven of the et 4) 437) the linear nonthreshola model Gib len. Mg aeses athe a. dsr tik Galen wasies Gat ih raters wavadeads per person-rad regardless @" paroboy tee dose dary bes not. th Afie-r fects ob ragiaion wthoueh ws ponereih oie ‘Tr oaluest never anpesis im wrervecs! . 7 é ta " chee 6 TSE TL at yt nee tts (ga Sate tore Blairs concert and re ces phagesrome Anke are Sp aMeeg ys Fewer GQ OMe Po went CF Gee lkae . Ae! lop see predpeecnszca cisadip.-oe oat hive cellectively accumulated the dove. . aye «SBR 6h AEELer BETERNBRC Hote YY eae.SPTaren epeemaTRNN rdog ayPEREORRem rte am endgi gt bog, co orien Ph irapitieeeineee ag ee ‘ , . wo te Feros re BRE . cro . L , rare , EE tte or cs BEE Bee RR a . o reo iss oon tart far een tumor repe, Gonna nn pete gpb y x eee SABES ke3 Hee : Cae er. wal UN, wee OM derils al the suarther of - Vast none of the studies. man er anit r ‘ a san five aosmorions usually . | ¥ Contrast, the analysis by Mays et af (79) cf “rc fe'ytonium, radium, ete.) shows a better - eee SIEMOK! Lo oOPsmip seen MM a tac bvery PC eecous aN Pepa don scat of expostire to cartroutiny of (homegenevts wna terms tot oris facters. ev vlreament. care. eto mas refleet rrimerily tne relating identity of ; . ‘e : thresholds in coat popuiation, thresholds mug vi vary much more ona highly heterogeneous. Suman populaden and the relation be fess sigrncid and rrore af padiostrantium and radiacalcium in at fata, dees not fit the dose-response i dow closes there is always a lower incidence ) canased group, Th f spurious!: =war, ret He alo cubs attendon io the ievpertant tact that a Gass & Lioyd CLIO) summarize § extensive oes . re . the e scoticr cf the data, Abolas Causes chide bos cegentis ported oul yte 2settled to even haute sumapcantiv. and show clearly that a 1 : in shape of The Sumves fitting argue’ ove the ar bet aye fies wand oss than con . A full-blown flaw dose domaip. rene s a . a aca Iwihte ‘oa, sats bre Ubeaeilde a otaa 345 ee cee epi ee ab eb ee -sean geither oe supported vor retuied without ae te “fy 7 kates TORICOLOGY OF RAD SUCLIDES N wt . a te ae Malet gee oe ta gy cee a : . Wah mw Ke ° . . \ ‘ ‘ fn : er eat creteCac t a ee Sab nee ue tat 4 a eda ei he et . » ten te sr a Deke bog ae Eu Ty Bester : eae tr re a wet ante Boy Babee