‘
7
:
.
;
i
Loan ake dere on tants Malasar Ra od bacLot
ba
Hanne. Yet the body burdens of all isato a.
i
as 2Sr- VY are se tow (weil Be. 4
tonal exposurs) that U2 autaer
aceupa
pr
rathogenic. They suggest a longer perins
hos. croup, before conc.iding that thos.
exposure.
ated oy the presence of radium ceeua in
‘
4
ereater than those of radium or cesium,
fastronuum exposure,
sted be relatabie fo ru
cr analysis is important since the ”
eual Phat ionizing radiation can and has
wats Sear 12; | Prinary2 interest fer this
» eanused to fall-out aad patients receiving
“yd diseases. The fall-out exposures are
in the studies with ratients, '?'T seems
.
4
L
.
rad
“i. unyroid carcinoma than comparable
itor of about 10.
a
oat
‘
nnd 135] seem to be more effective in pro-
ta tstad dases are more similar to external
that this difference may be due to the
colloid along
Poi line isotopes in follicular
to the other
red
compa
e
particl
beta
'd
eo
wortaid varcinoma in chitdrec. for external
. Ws-rodiatian and gamma ptotons) 1s 10-20
Voy t
yecrased persons (114). The nsk from ~ {
al vases per rad per million in children and
cdence from X-irradiation are about
mo
Pe posees.
wuhemia than from thyroid carcino.24,
wet the chances for leukemia induction trom
+. raraicosis. This has received more emphisis
'
carcinoma. In 1968 Saenger. Tioma &
ete
1! repert on a group OF 36.000 oatians
“Ythat there was no differen ein leukemia
“Te
f or thyroid surgery. Bu tach other
teakenna for hy perthyroid pa: IML» asa
sine gereral OLS. 7
Soper. deta dee ste
.
bowtie Rave bea dane. f
“naeaes
“erenege
eee Tan
mt
PTE
: ops= aes
—
-
-
Indnetion of carcmosamal aberrauens by iodine-isotopes has ben repozted
Niuwi. of the oat srTeation on ‘adiis-isctopes in animals utilizes reiauvely high
ee
fons. Recently Thorius, Scou & Chitcile (20) have reperted on the
abhi daw ide. uy ol cy
ISTE pot oniy at moder Rey
sud una injected
aie COse fewets But ot levels wos Jerel in the past as “contrat” or “tracer.
The average infinite beta radiation uoses to the thyroids of these animals ranged
from 797~4510 rads. The lowest infinite dase was 286 rads and the highest
18,603 rads. Thyrcia tumors, usually foliicular adenomas, occurred in ahi
animals including the controls, but tumor incidence in the higher level animais
was greater by a factor of about 3 over that in the control and low-level groups.
There were also alterations in the pituitary gland with pituitary adenoma
occurring after moderately high dosage. It 1s interesting to note that theve was
no ahereticn in life-span in animais maintained for a longevity study ©. tr
tnough some of them received accumulative radiation doses to the thyroid of
approximiaely 15,000 rads. However, biological change of a greater cr icsser
degree wus seen at all of the dose levels.
Other heta aid beva-gamune emitrers.—Bair (9) summarizes the incidence of
wie bite weer “Ce give n by wiuratricneal injection,
‘“Rae '' oan peiles
itnpeontie *} irap.ams, Co wire implants, '78Au, “"Fe. 27S, and '?Ru
after inhalation or injection. Sanders. Thomoson & Bair (12!) give an ex.pertment-bs-exnerimert review. Radiation do:2s to the lung are so high in WV thare
mitences itut it ts reasenable to conciede chat these nuchdes are celaiveny
incficien: Curcinogenic agents. However die studies do not ordinar:ty melude
many Jow-dose seginents or sufficient :ime really to determine the iong-term
potentialities of these nuclides. There is a report of teur squamous ci! care.La.
vey DDR ds ocape Cphaling '44Ce csils in ameunrs weoducicg es fo. oe
only up te 2500 ra. s and a Jarge studs “ith dogs recviving 1440Up cu rmeraiue
ints furcd eh iss crogress at the Leve.ace Foundation, Berke & Desc. ant
hod move polmoraery pathology than neoplasiic change in rats receiving vrese 5
‘so, tom
soma [ED-18s,
aeToi.
dt;
“4 TRAPTES Batjeeaa “he
i
rae apenas an gine LE PORamee
5
in meth animate C87 UeRy and mar t1igs
fe
cel
rary
ve wad thes fans
sos
whe BAST.
Or takeout than uses an iWQlly.
pioneer don,
i
fase
. 3
i
oO
a
he
a AST J, can produce thyroid
virog, cramarify
-
Pate
There was an epparert excess of acute leukemia m males receiving #311
(5 cases obserscd vers LS ¢ pecied) and a comparable Ceticit fu boc sexes
In viieihee Of a SRTapa Gc kee Komid (Zit onserved versus 4.8 exrecte
Trese undings ate .ompared to and touad consistcat with the data from the
ankslosing srocds lings and aren: bomb survivors. Torepams con udes thai
none of the siuaes demons rate induction of .eubkemia at low total-hody deses
ef radiadon cad thot)" 2 ucatment of thyroid disease curries no greater risk
:
.
‘
ne RAE tes AR
beetOS th tae re Ae wehteek ew abe = Ga beas A Ta RAT Ae
oa ND DOTE-ETSPONSE RELATIONSHIPS
‘
eowy. Parabooeos far udionuchdes 2re Mu? mere tame.
aw ut huis -Jaci’ vl Matiad. oes of loxcalogy, Tas arises in farce
pithe preci of radiation aici mests not to be satisfied scith such simple
woes
TEre
mM7
Pa aT meyer TET PTeres ipane Se a” anid
Ve
47pias
ptinbeapt ”" ageToot gPantpterhe epeage st Whingg Hae ewer nae ety dg Jot wy ane
eo
wer
‘
POT be te
ae ete
oe
Win Be whee
ny
yt TR ad
bet thee
we
Faget 1A a otideet he ieee speitie ate ed eeap oe
.
tos
patent
ph
ee
kre be
eee hla deg Tk Dh avy
rae seat