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the parnt and in the body buraen, furtiler anacysis is iMpurtuni since Ue .
curdens are generally conviderably greater than those ¢f radtuen o:
and eects, if they do aapear, might thus be relatable to radiostroniiut. WA
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A general estimate of the risk of thyroid carcinoma in chi'dren for externa!
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with the relatively low energy of the ‘?'I beta particle compared to the other
iodine isotopes.
’
forms of ionizing radiation (largely X-irradiation and tame plorons: is 1C-2>
additional cases per rad per million exposed persons (114). The risk from 1344
would thus be about i-2 additional cases per rad per million in children ani
Jeis in adults. Estimates for leukemia incidence from A-irradiaiion are about
29 additional cases per rad per million exposecs.
In view of the greater mortality from leukemia than from thyroid carcinoma
much concern has been expressed over the chances for leuxemia induction fron,
radioiodine in the treatment of thyrotoxicosis. This has received more emohas:s
recently than the induction of thyroid carcinoraa. In 1963 Saenger, Thoms &
Tompkins (11S) putlisned 2 preliminary report on a group of 30,0uU pauenl
(with 98.8 °% follow-up) which indicated that there was nc ailference in leusena
incidence between patients receiving '7'T or thyroid surgery. But wich ertce:
treatment the odserved mortality from ieuxemia for henectoyretd peneqs 4
group Was reporied us 50°54 higher than for the general U.S aap an Pr
kins fodowed this oreliminary ry report
with a more dara fot ots:
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The age-ad:usted feakoimia incicence rate was id per bor itad papers 5
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ducing thyroid carcinoma, and calculated doses are more similar to exiern.
radiation. Casarett (113) speculates that this difference may be due to Ub.
extremely nonuniform distribution of iodine isotopes in follicular colloid alors
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Other iodine isotopes '371, '354, and !351 seem to be more effective in
ihatiety: pies
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Redicivdine.—The fict that radioiodine, primarily '7'T, ean prot. es 2
carcins na im: animals is well-established. That ionizing radiaron .tr 2 + >
procuced thyroid neopasia in man is also clear (112s. Pruvniry i
review centers on the populations exposed to fall-out and peticits rho
radioiodine for the treatment of thyroid diseases. The riil-cui exmv 3.
considered under a separate heading. In the studies with petients, ‘7 'f secc
considerably less prone to produce thyroid carcinoma than comparable rac
doses of external radiation by a factor of about 10.
fy
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Alingugi the groups are complicated pv the presence of radmiry ie tens
ees
ue
ud
PCs) Radium C. and radon as well as “PSr-°FY are se dee ree
maaimum permissible bods burden for occuranoanal exsposars, thot 7 ol.
refuse ta believe the careinomias to be radinge te They suggest a for ger
of hehew-up and further anabysis of the group, before corciudiny wat iy
true incidence due to radiosircentium exposure.
Bee,
ory
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6 cases of malignant disease is only 0.0006, Yet the bods bur sis of eeu
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