DOCUMENT SOURCE
Lawrence Berkeley Laboratory
Archives and Records Office
RECORDS SERIES TITLE
Applied Science Division: Scientists’ Papers - Papers of William E. Siri
ACCESSION NO.
434-91-0131
FILE CODE NO.
19-14-18
CARTON NO.
R
COPY
7
FOLDER NAME
Agets
Dr. Leo Meyer (Marshall Island Natives}
NOTES
FOUND BY
Perry Hail
oe
oo eehe
-
--—.
a.
_
July 6, 1963
Leo M. Meyer, M.D.
South Nassau Communities Hospital
2445 Oceanside Road
Oceanside, New York
Dear Leo,
Shortly after mailing a note to you the other day I looked
up some of my old (unpublished) data on blood volume vs. TBW.
First of all, it is not the best of logic to estimate blood volume from lean body mass when LBM is in turn estimated from TBW;
blood volume from TBW makes more sense. Assuming it does, some
of my old data suggest the following formula:
RCV = 0,046 x TBW + 0,124
(liters)
This formula is still subject to modification, and there
is, of course, a respectable scattering of points about this
line for normal subjects.
You might also look up a paper by G.A. Zak and D.D. Earle,
"Blood Volume and Body Water in Normal Hospital Subjects," in
J. Lab and Clin. Med., 49, 504, 1957,
blood volume as:
They give a formula for
BV = 0.1183 TBW - 0,089
The results of the tritium assay of your samples are enclosed.
We included estinates of fat and LBM but left the job
of estimating blood volume to you, feeling that you would enjoy
the arithmetic.
The numbers for TBW look reasonable, and if you followed
ay original directions, they should by reasonable.
So far as
I can see there are no technical errors in the assays.
If you have any questions, send me a note or phone, but not
until after July 15 when I get back from Washington.
Best regards,
William E, Siri
WES : pb