t

Ipidini “to no}ssex4 arta “te. 9rs ‘emia yon 16 noisiess1 xbod: a ow
‘time post onset: ofuptake, days,

d

instantaneous fraction of atoms decaying per unit time, day”
~t

ao rbet

ri i

x

=
3
ee

aa

pple

p?

ett t TO%4-

rept

day~!,
initial atom ingestion ‘rate, “atoms toy
instantaneous fraction of atoma removed from compartment. i by

de Vai vidun euosne sandend

ot ee ramay Jad sina ums
snived
physiological mechanisms, day

compartment i deposition fraction,

the number, of,atdas /in“compartment i‘ relative, to the number in all
4

i

compartments at+the onset of declining continuous uptake, (t*0),
tour

gE

Pd

werd

oy.

Witob

ete bth tba a

instantaneous urine activity concentration, Bq &

uf!

-

gpalds

@eoiie!

maT Quatk

subject urine excretion rate, & day 1,

a

fraction from:Gl; FEaSt, to dloods s+, pe
fraction excreted by the urine pathway,

|

+
8G ba

|

5

st

instantaneous fraction of atoms removed or added to the atom uptake
ma.

Pray!

a

ett

7

:

(ype

ery

Yo

i?

atu

de

i

per unit time, day~*, due to dactore® ot er. than radioactive decay,
wet

ou

2

instantaneous body burden, Bq,

cat
ee
body burden at the onset of uptake, ‘Bq,

ed

utah

sey

ee

the number of disintegrations in all compartments occurring ‘during
the uptake interval, Bq days,

.

:

The development of Eqs. (1), (2), and (3) was based on the following convolution integral.

At some variable time, T, defined during a fixed uptake

interval, T, the daily activity ingestion rate crossing the gastrointestinal
tract to blood is given by

ures

“4

SOM

o

e

~(ketdr) Tt

e

aya ee Re heats Preeoy!

rote
Pete.

AEP

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