cA. BEIR-L. 3 Sm —— 1. Cancer (Tables 3-3 and 3-4) Derived Cancer deaths/year in U.S. Cancer deaths/10° person rem from 0.1 rem/year ina (pop = 197,863,000) Absolute Relative Absolute 516 738 26 37 30 year elevated risk 1210 2436 61 123 lifetime 7485 8340 75 42) Leukemia Relative Other Cancers elevated risk Range 1726-2001 3174-9078 87-101 160-458 From the above the minimium estimate of cancer risk would be given by a risk coefficient of 87/10° person rem and the maximum by 458/10° person rem. Thus, these two risk coefficients were used to define a range of estimated cancer deaths. —— 2. —_——o Génetic Effects (from Page 1 & 2 BEIR-I) ae @. Based on specific sore® fe os rem/30 year reproductive generation would cause jn the ( first generation 100-1800 cases of dominant diseases and defects per year (3.6 million births/year) or 5 times this amount at equilibrium. The 1800 cases represent an increase of 0.05% incidences per year first generation and 0.25% at equilibrium.