me on oP] Alerclee . 4 of [pom Ct ake a, 5 , fe atALE tefec - . , Ail eA, 5 rlLees [sige Ss one f Lhtak. Lite ty, nee Fe 100-1800 cases of dominant diseases and defects per year (3.6 million births/ year)=, Loeae Vera ¥ -! ‘ move .tee d tag Coe: Le Metee w . f, t) itvv wee Le” CSpo ~ rw ¢ Se we metag i. oe Qaren wt. vege lteter the ee. : /F22 wot , ars ; one “ An Hh fre Serene fren J 7 Os ; 7 -7 } bo / Ae / yee Tana x e J, : a “A *, . wo ae nae vo,Fs” ae f Aa “ ih toeee “es wee vse . tere byt ted he In additiona few chromosomal defects and recessive diseases anda few congenital defects due to Single gene defects and chromosome aberrations : wg feeptti hecen 5 7 *4 Total incidenc 184100 to 27,000/year, 744, at equilibrium@ rebrtom A. PT amb reee beret | Tor 0.18 Fin the first generatiof), Thee . . ’ ine. epaecinted em “ os }5 7 va fe oer. wef ma OCB TO lem os BE fad Sion On Jy a ¢: oe . . " pat ¢ é Z. . lo. 7 J 7 ao tee, wll . a ’? : ¢ Lh poe & fe : Overall] i11 health: 5% - 50% of #11 health is proportional to’muta‘ion ratea Oe bh ~Using 20% and doubling dose of 20 rem, 5 rem per generation-+“>5% increase in i1] health, lye tee " aly. fetieke Joe. oS / Ainnf