ORIGIN OF RISK COEFFICIENTS I. BEIR-I A. Cancer (Tables 3-3 and 3-4) BEIR-I Derived Cancer Deaths/year in U.S. from 0.1 rem/year Cancer Deaths/106 person rem (pop=197,863,000) Absolute Relative 576 738 30 year elevated risk 1,210 lifetime elevated risk 1,485 Leukemia Absolute Relative 26 37 2,436 61 123 8,340 75 42] 3,174-9,078 87-101 160-458 . Other Cancers Range 1,726-2,001 B. Birth Defects (page 2) 5 rem/30 years ————®100-1800 cases of dominant diseases and defects per year (3.6 million births/ year)=0.05% incidence per year (5 X this at equilibrium) In addition--a few chromosomal defects and recessive diseases and a few congenital defects due to single gene defects and chromosome aberrations Total incidence is 100 to 27,000/year at equilibrium=0.75% at equilibrium or 0.1% in the first generation Overal] il] health: 5% - 50% of 711 health is proportional to mutation rate Using 20% and doubling dose of 20 rem, 5 rem per generation—* 5% increase in i1] health 5%/5 rem in 30 years at equilibrium or 1%/5 rem in first generation = 0.2%/rem - 30 year dose