Nie =} wy a tN PAA: egy G PL ererke re Exposure to External and Internal Radiation - Project Title: Medical Studies of Marshall Islanders and Study of Radiation Effects on Intracellular Mechanisms Reiterarion of Assurance Statement RX-01-01-fa) on Investigation Involving Human Subjects Including Clinical Research The Hospital of the Medical Research Center, Brookhaven National Laboratory, complies with the policy for the protection of human subjects participating in activities supported directly or indirectly by grants or contracts from the Department of Health, Education, and Welfare and from the Atomic Energy Commission. In fulfillment of its assurance, this institution has escablished a standing committee to review investigations involving human subjects, in- cluding clinical research, and said committee is charged with responsibilities to determine for each proposed study that: the rights and welfare of each patient will be adequately protected, that the potential benefits outweigh the risks, and that an informed consentwill be obtained from each patient, The committee, appointed by the Director, Brookhaven National Laboratory, provides for independent judgment of its members, and alternates are provided to serve when there may be conflict of interest, This institution encourages constructive communication between the committee and principal investigators on the safeguarding of the rights and welfare of subjects; will provide the required care for persons injured as a result of participation; and maintains complete documentation of proposals and reviews. Approved investigations are reviewed by the committee at least annually and the institution periodi- cally reviews its practices and procedures to assure they are consistent with the policies published by the Department of Health, Education, and Welfare. As of March 7, 1973, the Institutional Review Committee for review of Medical Department research activities involving human subjects is composed of: J. G. S, E, G, S, Robertson, M.D,, Chairman C, Cotzias, M,D,, Alt. Chairman H, Cohn A. Popenoe, Alt, for Dr. Cohn Chikkappa, M.D. G,. Price N, P. Rathvon, Jr. D, N, Slatkin, M.D., Alternate A, P,. Wolf, Alternate L. K, Dahl, M.D. + Clinical Consultant H, Connell W. R, A, Love, M.D, A. Finn - Administrative Consultant C. W. Flood - Health Physics Consultant Signature: — Title: Date: p19 10 Chairman, Medical Department March 7, 1973