Nuclear Medicine Technology and Other Health Applications Project Title: Lymphocvtopoiesis and Transplantation Immunology 13. Publications: Joel, D. D., Hess, M. W., and Cottier, H., lymphocytes to Peyer's patches in neonatal mice. Aspects of Immunity, 141-7, pp. RX-91-03-(d) Massive migration of thymic Morphological and Functional Lindahl-Kiessling, G, Alm and M. G. Hamna, Editors, Plenum Press, New York, | LEE “os 1971, Van Bekkum, D. W,, and Cronkite, E. P, Radiation effects on the lymphoid Systems and its functions. Progress in Immunology, pp. 1205-9, Academic Press, Inc,, New York and London, 1971. Joel, and lymph, oe OR fois D. D., and Cronkite, E, P, Extracorporeal irradiation of blood Presented at National Conference on Research Animals in Medicine, os TY Washington, D. C., January, 1972, Zt. “x Burlington, in culture, H., and Cronkite, E. P. Exp. Cell Res. (in press), Set Characteristics of renal ‘glomeruli __ Shae SS Chanana, A. D., Joel, D. D., Schaedeli, J., Hess, M. W., and Cottier, H. Thymus cell migration: 3HTdR-labeled and THETA-positive cells in peripheral lymphoid tissues of newborn mice, Presented at the 4th International Conference on Lymph, Tissue and Germinal Centers in Immune Reactions, Dubrovnik, Yugoslavia, June, 1972, bir Gok Chikkappa, G., Boecker, W, R., Borner, G., Carsten, A. L., Conkling, X%., and Cook, L, Bone marrow (BM) cells of chronic myelocytic leukemia (CML) patients cultured in diffusion chamber (DC) system. Proc. Soc, Exp. Biol, Med. (in press). , pit . , 29 —~ (ay Cronkite, E, P. Radiosensitivity of lymphocytes. Presented at the _ * ~ of Conference on Radiosensitivity, Freiburg, Germany, September, 1972. / fa s ‘ Greenberg, M. L., Chanana, A, D., Cronkite, E. P., Giacomelli, G., Rai, K. R., Schiffer, L. M., Stryckmans, P, A., and Vincent, P. C, The generation time of human leukemic myeloblasts, J, Lab, Invest, 26, No, 3, 245-52 (1972). Wagner, H. P., Cottier, H., and Cronkite, E. P. Variability of prolifer- ative patterns in acute lymphoid leukemia of children. 176-86 (1972), Blood 39, No, 2, y 14. , Toa’ aoe: *200 Word Summary: The overall objective in these studies is understanding of the factors controlling cell proliferation. Specific objectives are: a) to define anomalous cell proliferation in human diseases such as leukemia, auto-immune diseases and malignant lymphomas; b) to better understand the mechanism of allograft reaccion and evaluate ECIB and ECIL in the management of allotransplants and in the therapy of human (See Continuation Sheet) 1119225 / ‘ (of RX-67