Project Title: 18, It Molecular and Cellular Radiobiology Effects of Radiation and Chemicals on Control of Hemopoiesis Expected Results in FY 1975: (Cont'd,) RX-OR-O2- fh) is hoped to develop the diffusion chamber technique as a means of studying the mechanism of acrion of known hematopoietic depressant drugs. If personnel and time permit attempts to grow diverse human cancers in diffusion chambers will commence with the objective of assaying the effect of radiation and chemotherapeutic agents on the cancer cell growth. 19. Description and Explanation of Major Materials,Equipment and Subcontract Items: FY 1975 Capital Equipment: “~ Miscellaneous equipment requirements for this budget activity are estimated at $20,000 and include an input and retrieval terminal, two cyto-centri- fuges, microscope, and a portable laminar flow enclosure. $20,000 is allocated as one half share in the blood cell separator reported in Paragraph 19 of RX-01-03-d; and $25,000 is prorated to this activity for one quarter interest in the autoradiographic grain counter and cyto-analyzer reported in RX-01-03-d. 20. Proposed Obligations for Related Construction Projects: None ‘ (See Continuation Sheet) RX-233 1119293 ae