Exposure to External and Internal Radiation In Vivo Measurement of Radionuclides in Man; Body Burden and Project Title: Kinetic Factors, Computer Applications RX-01-01-(b) 15. Relationship to Other Projects: (Cont'd.) Research Reactor Centre, Glasgow; Remenchik, Argonne National Laboratory; Forbes, University of Rochester; and Burkinshaw, University of Leeds, have all measured whole-body potassium with high precision. Two groups are presently involved in total body neutron activation analysis (TBNAA) for calcium measurement: Chamberlain, University of Birmingham, England; and Nelp-Palmer, University of Washington. The current proposal on minimal radiation involves lower doses of radiation than have been involved in other known experiments. Related work on the positron coincidence imaging method is actively pursued at the Massachusetts General Hospital, Boston, by Dr. Gordan Brownell's group and at McGill University, Montreal, by Dr. Yamamoto. This is further related to the problems of tomography, on which a number of other approaches were discussed at a recent symposium, the proceedings of which are to be published. 16. Technical Progress in FY 1973: Many studies involve neutron activation analysis and calcium kinetics. In the study on the effect of the administration of synthetic calcitonin : together with dietary calcium and phosphorus supplements, the period was extended to 1-2 years and the number of osteoporotic patients was increased to 35 to include some administered human growth hormone rather than calcitonin. Following calcitonin administration clinical improvement was evidenced by a decrease in back pain and a cessation of spontaneous fractures as reported last year. The results following human growth hormone administration await completion of six months of therapy. : In the study on renal osteodystrophy, in vivo neutron activation analysis and whole-body counting techniques were used to measure the body composition in an additional 30 with results confirming those reported last year, In collaboration with Dr. Pierson, St. Lukes Hospital, New York, a serial TBNAA study of the changes in body composition and calcium metabolism both pre- and post-transplantation was initiated for 12 patients scheduled to receive kidney transplants. In the study on effect of calcitonin on Paget's disease initiated by Dr. Wallach, Downstate Medical School, Brooklyn, 12 patients have now b followed for one year while receiving calcitonin treatment. All of these Saitients show a higher than normal level of body calcium along with a greatly. increased bone turnover rate. The continuing studies on endocrine dysfunction are conducted to quantitate the changes in levels of calcium, sodium, chlorine, and phosphorus in patients with disorders of the thyroid and parathyroid glands as well as in acromegaly, diabetes, and Cushing's disease. These studies are carried on in collaboration with Drs. Roginsky and Aloia of the Nassau County Medical Center, New York. (See Continuation Sheet) FE 194i 1b RX- 16