Effects of Radiation on Living Organisms Radiosensitivity of Immune Responses and Mechanisms of Project Title: Immune Reactions RX-03-O1-(b) 13, Publicacions: Terres, G., Morrison, S. L., Habicht, G, S., and Stoner, R. D. Appearance of an early "primed state" in mice following the concomitant injections of antigen and specific antiserum. J. Immunol. 108, No. 6, 473-81 (1972) 77 Fy/ Hess, M. W., Cottier, The intestinal H., Sordat, barrier to bacterial B., Joel, invasion. D. D., and Chanana, A. Presented at D. the Conference on ''A Re-Examination of "Non-Specific'' Factors Influencing Host Resistance", Bern-Gurten, June, 1972, 14, 7 / 7604 . Scope: A) 200 Word Summary: A goal of this research is to determine the origin, of lymphoid cellular elements in immune responses. “N function'and fate Of primary interest are the highly immunogenic properties of complexes of antigen-antibody as compared with the same antigen administered alone. Five inter-dependent objectives are explored: (1) radiosensitivity of antibody responses, (2) comparative antigenic properties of complexed antigen and antibody (specific immunoglobulins) in their capacity to-elicit early and enhanced primary antibody responses, (3) cellular proliferation in germinal centers of lymphoid tissues during antibody responses, (4) rad- . ~* iation-induced susceptibility to anaphylactic shock, and (5) the genetic control of antibody responses, . Another goal is to determine whether or not tumor virus infections and ‘ ~ tumorigenesis are affected by exposure to radiation, and to compare the effects of radiation on in vitro and in vivo virus replication. determine if exposure to radiation will: It is proposed to (1) enhance or depress both in vitro and in vivo infection of cells with DNA and RNA tumor viruses, (2) influence oncogenesis in genetically susceptible and resistant infected chickens, (3) initiate tumors in non-infected chickens, and (4) influence the immune response in genetically susceptible and resistant chickens infected with DNA and RNA tumor viruses, B) with glob body Supplement to 200 Word Summary: protection normally conferred to individuals by active immunization igens and vaccines and/or passive immunization with specific immuno- rs in the control of infectious diseases may be abolished after whole- Sure to sub-lethal doses of ionizing radiation. Exposure of animals to ionizing radiation at various times before, during, and after immunization affords a unique opportunity to study cellular and humoral immune mechanisms as well as the repressive effects of radiation on normal immune responses. Emphasis is directed in these studies to the highly immunogenic properties of complexes of antigen and antibody in eliciting earlier and enhanced antibody (See Continuation Sheet) [119268 RX-175