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MONTHLY STATUS AND PROGRESS RRFORT
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Divialon of Blology and Medicine
#25
MORTH OF JUNE, 1953
coting the effects of teria netalt, both radioactive and nonrediosstive,
with special emphasis on plutomius and beryllium, Fositive results have
been achieved in the treatuent of experinzental plutonium and yttriuz poisonding by sirconium salts and in acute experimental beryliiosis by surintri-
carboxylic acid (474).
In recent tests with mice, sirooniun oltrate given
before or within an hour after plutoniue injections caused: a) a marked
inerease in plutonium excretion (spproximetely 136 to an mich oe a0.
of injected dose);
and b) a decrease in the amcunts deposited in the bone
(approximately 65%
to 10% of the dose). The effect of yttrium is similar
but less marked,
In mice injected repeatedly with an LD-95 of beryllium sulfate (0.7
/kilogram body weight), it was found that adainistration of
marimtricarboxylic acid following each berylliun injection not only protected the animals but enabled them to survive while still containing lethal
amounts of beryllium, Studies elucidating the mode of action of ATA have
a eee este for the Selectionef other compounds of potential
therapeutic value as well as a insight into some of the chemical mechanisns
involved in matal-ensyme interaction.
Studies ca Passive Temunity. (UNCLASSIFIED) Experiments have been under
nchAver
Doratory
designed to test the effect of whole
poly gumin irradiation on immcity nochend ves. A Cobslt-60 source was used
for the studies and radiation dosages of approximately 650 reentgens equiva-
Lent physical (the LD-50 being 750 repe) were administered to mice.
Evaluation of the results shows that while irradiation effectively
destroys the imumarity te pnewnccoccal infection even in the presence of
abundant specific antibody, it does not abolish active imamity to the infinenza Type A virus, nor the activity of tetams antitoxin present at the
time of irradiation. Taken together with other bits of evidence, this
finding suggesta that the lowered antibacterial resistance following wholebedy irradiation is attributable primarily to the failure of phegocytosis
by reason of the white call deficiency, and that this phagocytosis may not
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