,
2 to each person differed deis cabin.
"I was inferred as about 20 to
y in the thyroid region during
found in the urine samples
The radioactivity decreased
m the activity in the urine was
om the fatal case showed that
rs when compared with the
IMURA et al., 1956).
‘x content in the urine of the
the same time the results cf
rence between fishermen and
Hematological Effects on Heavily Irradiated Japanese Fishermen
HEMATOLOGICAL OBSERVATIONS
l.
Leukocytes
The total number of leukocytes decreased gradually, showing minimum
counts at about the 4th to 8th week after the exposure.
In
one case, the leukocyte level was depressed to 800. A correlation was found
between these minimum counts and the doses of individual external irradiation.
Similar relationship was found between minimum counts of neutrophils and
the dose as shown in Figure 2.
2500
= 2000
-
3 1500
:
3
ns in the early stage.
Five cases revealed a
count of less than 2,000/mm3, 13 less than 3,000, and 5 less than 4,000.
1y an impotant role in early
EARLY STAGE
67
Fig. 2
Correlation
between
the estimated dosesto the whole
body and the minimal number
of neutrophils.
.
= 1000
5
°°
ste
"e
500
dose of lst day 70
dose during 2weeks 100
e
130
200
190
300
:
7
*
250
400
310
500
°
.
370
600
430
700
490
800
R
R
In most cases a shift to the left of the neutrophils was observed. Staff
cells increased in early stage and then gradually decreased. However, in
some cases, metamyelocytes and myelocytes appeared in peripheral blood
especially with the begin of recovery. In a fatal case who died of liver
damage, a considerable number of juvenile neutrophils were observed at the
end stage. Lymphopenia was noted between the 2nd and 8th week in all
cases.
Leukocyte count began to increase after the 8th week.
In manyeases
eosinophilia was remarkable, especially with the indication cf recovery.
Eosinophilia continued in somecases for several years without proof of parasites,
and one case still revealed slight eosinophilia in the 1968 survey.
2.
Erythrocytes
At the time of hospitalization a few patients were anemic. Noreticulocyte
was observed in them at the critical stage. Color index was higher than 1. 0.
The Price-Jones curves of erythrocyte diameter were displaced to the right
of normalat first, and returned to almost normal after one year.
These changes
corrseponded to changes of erythroblast diameters in bone marrow.
3.
Platelets, ete.
Platelet counts decreased, reaching a minimum in the 4th to 7th week.
Most of the fishermen revealed the values below 100,000/mm':
Fig. 1 Symptons arid Sign
s in
the early stage.
The results
of other tests related to hemorrhage showed depression at the critical stage
in general and recovered by the 10th week.
4,
Comparison with Other Irradiated Cases
When these blood changes are compared with the changesof other irradiated