Appendix V Findings of Epidemiological Studies of Cancer in Irradiated Populations (From J. Shapiro, Radiation Protection, pp. 260-4, Harvard U. Press, Cambridge, MA, 1972) No of cases Subject of study 1. Hiroshima and Nagasaki A-bomb survivors (bomb exploded 1945) Follow-up Dose No. of Form of Observed in exposed Expected if not time ¢y¥r) (R or rads} persons® cancer group? exposed’ Leukemia Leukemia Pa 6 19.1 30 $-13 Brillet al, 1962 (81) 2. Hiroshima and Nagasaki A-bomb &1-320 13-2) survivors (women). Wanebo etal, 1968 (238) 3. Hiroshima and Nagasaki A-bomb 8695 Leukemia 24 20 3,082 Breast cancer 3 7.3 10-39 1.262 Breast cancer 5 3 1,292 All cancers l 075 1.215 All cancers, control 10 85,070 13.184 0-9 40-49 90-199 >200 Unknown Unexposed >64 500 survivors exposed prenatally 857 802 84] 840 2.458 Breast Breast Breast Breast Breast cancer cancer cancer cancer cancer 2 5 6 2 2 2 2 2.3 2.3 6.1 person-rads4 Jablon and Kato, 1970 (93) 4. Japanese A-bomb survivors exposed 0-20 21-80 17 within 1400 m of detonation (died 1950-1962). Angevine and Jabion, autopsies 61 56.8 9 10.5 except leukemia 1964 (95) 5. Children exposed prenatally due to abdominal x-ray to mother (exposed 1945-1956 and died before 2-)2 39,166 Leukemia 77 000° All cancers end of 1958). Court Brown et al., 1960 ( 239} 6. Children exposed prenatally (born in 1947-1954 and died before end of 1960). MacMahon, 1967 (240) 4-13 1-2 7. Infants who received irradiation of 13-38 61-600 chest before age 6 ma. in treatment for enlarged thymus (treated Lower dose 85 60 Thyroid 4 0.07 Thyroid {benign} Leukemia 6 3 80 1.45 Higher dose Thyrotd graup Thyroid (benign} 498 Leukemia (11,485 per- 14 15 3 06 .60 37 Thyroid carcinoma 0 0.03 Leukemia 0 0.95 group 2,207 1926-1957, follow-up in 1963). (32,226 per- Hempelmann et al , 1967 (160) son yrat — riski! son yr at risk} 8. Infants irradiated routinely with 10-20 X-rays to anterior mediastinum 75-450 mostly 150 1 401, includ- through smail (4 X 4 cm) port, ? ing 244 days after birth, as ‘apparently harmless and perhaps beneficial with enlarged procedure’ (x-ray 1938-46, fol- thymus low-up 1956-58). Contiet al., 1960 (146) 9. Children treated with x-rays to head, neck, or chest for various benign conditions, mainly ‘‘enlarged”’ thymus and adenitis, treated before age 16 and fol- >I (83%) <50 (4%) 1 644 50-200 (361%) 200-600 (33'%) 11 0 Thyroid (benign) Thyroid 7 0 Leukemia 7 1.4 lowed till age 23. Saenger et al., 1960 (202) 10. Children treated before age 16 with x-rays for enlarged thymus, pertussis, and head and neck diseases; and dred before age Upto 23 Not given 23 (treated 1930-1956, follow- up 1940-1956). Murray et al.. 19§9 (241) - 134 - 3,872