Edward Gleason, et al v. NUMEC, ~, settled out-of-court. This suit was eventually A discussion of the evidence in this case by one of the authors is presented in the Appendix B of this revort, rns | These two cases, drawn from the relatively small number of individuals so contaminated, strongly suggest that Pu-239 particles offer a unique carcinogenic risk. They indicate that a single varticle is capable of delivering an intense radiation dose to a critical volume of tissue and that this disruptively irradiated tissue, lixe an atrophied nair follicle, nas a hich scroDability (maybe as high as 1/1000) of becoming cancerous. C. ‘ Related Lung Exveriments The sxin experiments with animals are remarkable in that a highly disrustive dose of radiation to a small portion of revairapie mamnalian tissue produced frequent carcinogenesis. The chance of sroducing one cancer ver animal is essentially unity. It is reasonable to expect that a comparadie develooment could occur in lung tissue. , while a number of radioactive substances have been used to induce lung cancers in mice and rats", it is difficult to derive any characteri2z:3tion of carcinesenesis from these txperiments. 38/ Cember, H., “Radiogenic lung zancer," Progressin ixperimental Tumor Research, FP. disourger, ed. New York, Hainer Puslisnhiqs Company, Inc,, Vrl. 4, 1954, sp. 251-303. Apr: Te a eee Fw er dew me neg oe weegnre toe