) =~ 27 sensitive to such intense «= localized radiation. cc. C. Lushbauqh renorted on a lesion that developed as the result ez residual Pu-239 contained 0.08 uc from a puncture wound /®, (0.905 uCi) of Pu-239, The particle Commenting on tne histological examination of the lesion, the authors State, "The autoraagiocraphs showed precise confinement of alcha-tracks to the area of maximum damage and their cenetration into the basal areas of the epidermis, where ecitnelial changes tvcical of ionizing radiation exposure were cresent. The cause ana effect relationship of these findings, therelore, seemed cbvious. Although the lesion was minut canis ce a tb “litimate than 9.1 ug of cnances in humen ctissze. fag ‘erv intense. fate of such a lesion should it without surgical intervention..." ct ul ‘ th oO less je Ur mn!) Oo 0 case, Their similarity to known twicearmal cytologic changes, of course, raised cP 0 a oO tJ oO a 0 4 I QQ 3 re] wv cr hk |a fu ti) u (a 3 rt ( 4 tb 0 (a J one changes in it were severe. Pu-239 In produced precancerous The dose to tne surrounding tissue There is every reason to believe that a s~aller quantity ci Pu-239 would have produced similar chances. TALS orecancerous Lesion indicates that a single Pu-239 zi ’ a significant inducing cancer. ! oO it 5 b - fu ‘O fu oO “ I fy 5 he carticle irradiates Lusnbaucn, C.c. and J. (critical) volume of tissue The Lushdaugh study was Langham, Oo. cit., po. 461-454.