‘
;
;
;
, 33
is essentially a review of his analysis,
which has become
known as the "Geesaman hypothesis."
A
Tne Geesaman Hyoothesis
Dr.
Rov E. Albert and co-workers performed a number of
experiments on the induction of cancer in rat skin?4736,
Albert's study of radiation-induced carcinoma in rat skin
cives some cuantitative description of a high-dose car-
wd
A skin area of 24 cm? was exposed
diation with various depths of maximum penetra-
4
Ww
I-
tion.
wo
Qo
ct
4
0
a
cr
Qo
cinesanic situation.
The dose response curves are revsroduced in Ficure l.
In all cases che response at sufficiently high doses
(1000-
3909 rem} was large,—~1-5 tumors per rat by 80 weeks post
'
.
exoesure.
It was noted by Albert that when the dosewas
mormalizec tc a skin depth of 0.27 milinmeters,
resconse carves Decame continuous
Geesaran,
5
‘ys
33/
D.P.,
.2.,
{See Figure 2).
UCRL-50387 Addendum,
F.J.
Burns,
and
the three
R.D.
Op.
Since this
cit.
Heimbach,
"The
eilece ci
svenscration depth of electron radiation on ski
tenor forracticn in the rat," Radiation Res. 30, 1967, po.
357
ena
ens
Slperc, R.5., F.J. Burns, and &.D. Heimbach,
515-524.
"Skin camage
oturcr fiirration from grid and sieve patterns of electron
beta r2iistion in
the
rat,"
Radiation
Res.
30,
1967,
Albert, R.E., F.d. Burns, and R.D. teimbach, "The
34/
zs3cciation 2etween chronic radiation damage of the hair
follicles and tumor formation in the rat," Padiation Pes.
1357, oe. 2399-593.
sp.
30
325--