‘ ; ; ; , 33 is essentially a review of his analysis, which has become known as the "Geesaman hypothesis." A Tne Geesaman Hyoothesis Dr. Rov E. Albert and co-workers performed a number of experiments on the induction of cancer in rat skin?4736, Albert's study of radiation-induced carcinoma in rat skin cives some cuantitative description of a high-dose car- wd A skin area of 24 cm? was exposed diation with various depths of maximum penetra- 4 Ww I- tion. wo Qo ct 4 0 a cr Qo cinesanic situation. The dose response curves are revsroduced in Ficure l. In all cases che response at sufficiently high doses (1000- 3909 rem} was large,—~1-5 tumors per rat by 80 weeks post ' . exoesure. It was noted by Albert that when the dosewas mormalizec tc a skin depth of 0.27 milinmeters, resconse carves Decame continuous Geesaran, 5 ‘ys 33/ D.P., .2., {See Figure 2). UCRL-50387 Addendum, F.J. Burns, and the three R.D. Op. Since this cit. Heimbach, "The eilece ci svenscration depth of electron radiation on ski tenor forracticn in the rat," Radiation Res. 30, 1967, po. 357 ena ens Slperc, R.5., F.J. Burns, and &.D. Heimbach, 515-524. "Skin camage oturcr fiirration from grid and sieve patterns of electron beta r2iistion in the rat," Radiation Res. 30, 1967, Albert, R.E., F.d. Burns, and R.D. teimbach, "The 34/ zs3cciation 2etween chronic radiation damage of the hair follicles and tumor formation in the rat," Padiation Pes. 1357, oe. 2399-593. sp. 30 325--