depth is near the base of the hair follicle which comprises
the deepest reservoir of epithelial cells of the germinal
layer,
it was suggestive that this might be a critical
region in the observed carcinogenesis.
The suggestion gained
sianificance from the observations that most of the tumors
are Similar to hair follicles,
and that in the non-ulcerogenic
Gose range the number of tumors per rat was in nearly constant
razio
(1/2000-1/41900)
with the number of atrophied hair
Thus the carcinogenesis in this experiment
N25 remarkadly correlated with the dose to and specific
of
a varticular skin
structure.
When exposures were
stripe and sleve patterns of reughly 1 mm scale,
geometrical efiects ware observed:
moSt nowtadly the cancer
inguction in the sieve ceometry was suporessed at doses of
cr
1790 rad but not
at doses of 2300 rad.
The reduction,
however,
w25 acain consistent with the reduction in Gamage as characterized
cnis important experiment, a high incidence
cancer was cbserved
after
intense
local doses of radiation,
arcinocenesis was proportional to the damage or
qr
ae
®
a
w
ay
Z
of
ty
oO
To summa
ty
by atrophiec hair follicles.
2rtordering of
3
gritical
architectural
unit of the
tissue,