Others have observed carcinomas and sarcomas in rats and mice after intense exposure of the skin to ionizing radiaCancer induction is generally a frequent cvente A . tion?!” 3, 1 . _ Even at elevated doses, such as in these experiments. 12,000 rad of 1 MeV electrons, . -S5 sarcomas/100 cm2 in rats A few results Withers, H.R., 37 for rabbits, sheep, ootained at Hanfora?® 4}. 37/ Boag and Glucksmann induced Despite and swine were the small number of animals "The dose-survival relationship for irradiation of epithelial cells of mouse skin,” Brit. J. Radiol. 40, 1967, pp. 187-194. 38/ Hulse, E.V., “Tumours of-the skin of mice and other uelayea effects cf external seta irradiation cf mice using 90Sr and 32p Brit. J. Cancer 16, 1962, po. 72-86. 39/ Boag, J.W. and A. Glucksmann, "Production of cancers in rats by the local application of Beta-rays and of chemical marcinogens," Proaress in Radiobiology, J.S. Mitchell, B.E. Holmes, and C.u. Smith, eas. Proceeuinds of the Fourin International Conference on Radiobiology held in Cambridge, 14-17 August 1955. Edinburgh, Oliver and Boyd, 1956, pp. 476-479. F 40/ George, L.A. and L.K. Bustad, “Gress effects of beta rays on the skin," Hanford Atomic Products Operation, Biology Research Annual Report for 1956, HW-47500, 1957, pp. 135-141. 41/ George, L.A. II, R.L. Pershing, S. Marks, and L.K. Bustad, “Cutancous fibrosarcoma in a rabbit following beta irradiation," Hanford Atomic Products Operation, Biology Research Annual Report for 1959, HW-65500, 1960, pp. 68-69. 42/ Ragan, H.A., W.J. Clarke and L.K. Bustad, "Late effects of skin irradiation," Battelle-Northwest Laboratory Annual Report for 1965 in the Biclogical Sciences, BNWL-280, 1956,pp. 13-14. 43/ Karagianes, M.T., E.p. Howard and J.L. Palotay, BattelleNorthwest Laboratory Annual Report for 1967 to the USAEC Division ote 0 . Me ee ae tl eae ee “1 ‘ nn 7 , ee Me. eo . lo, eats . cot tay : Sake ceed, yo, Ma sat tee : aS riot ter. 4 - ‘os « . ats . SOR . . fe - PS . ' +. me ‘ Ve a ag SS UY pomer oney tat ge roa* met . see oY “Tt meoad vetas . ple . hye Fel oR ape a “at ok? . an : tome : --m-y- a e om RF BA a me ie : ; wae et ae eta ro eS\ eve ee 8SAE “ee vo heyt of ety’: Se pas : wey ¥ 1 as a : a . . a 4, PT te iy “or . Dose I, Biological Sciences, BNWL-714, “2! of Biology and Medicine, Vol. 1968, pp. 1.10-1.11 Oe fet et > te .