period of time while they were beins chroniccily exposed to radiation.
hematologic studics sugsest that dofinite chanses were induced.
The
The article
Gemonstzates the difficuitics and the potcntiatities of this type of analysis.
8.11
The lMomorshagic Syndrome of Radiation Iliness.
In previous ecitions of this book, a long detailed discissuion of the
various facets believed to contribute to hemorzhaze were discussed.
coatsoversy has been resolved.
Much of. the
Historically (Fornau, Schzanck and Zarzychki;
Fabricius-Mollcer; Lacassague, Lattes and Lavedan; Shouse; Warren and Whipple)
ebserved hemorrhage.
The most critical observaticns on pathogenesis were made
by Pabricius-Molier who corrselated platcict Levels with bleeding and noted that
lead shieiding of a leg during ircadiation proavented Later bleeding and the
thrombopenia wes much less marked.
chicidins.)
(See
Chepter 10 for detailed discussion of
Alien ond associates cisined thet hepasinemia was a major cause of
bleeding in addition te the thrembopenia in izraediated docs, and that
penia actually sensitizes to heparin.
the thronbo-
Of the Latter there is little doubt.
concept of increased amounts of circulntins
The
heparin was readily accepted, probably
gencral, been refuted (Jackson et ai.}.
apasinenia concent has, in
a
ry
wo
because positive treatment by antihepasin could, in large part, control the biced-
The psos cnd cons are discussed in previ-
ous editicns of this book end in a review by Cronhite and Brecher.
ne following defects in hemostasis that lead to bleeding scem to be well
documented.
<A progressive thrombopenia develops that is timce and dose-dependent.
The thrombopenia leads to a quantitative deficiency in clot cetsaction, prothrombin utitication and capiilary intesrity.
Lastly, at very low platclet levels
with virtually no prothrombin ccnycssien, the whole blood-clotting time becomes
remazi:ably prolenced.
Uicerations, trauma and infections inczease
the bleeding
tendency (Cronkite; Croniite and Srecheos, Jackoona et al., and LeRoy).
The most dizsect evidence cn the sole of the platclct has been the proof that
| | Qactetes transfusions wiil prevent bicecing or stop biceding that has albready