In 25 percentile of population having elevated lipoproteins - 7 In 5 percentile of population having -15 Diabetes Uncontrolled before insulin 1900 Controlled with insulin _35 Rapid pulse Phlebitis ~ 3.5 3.5 Varicose veins _ Epilepsy -20.0 Skull fracture . Tuberculosis - 2.9 - 1.8 Nephrectomy - 2,0 0.2 1920 Joslin Clinic record 1940 Joslin Clinic record ~20 15 . . Trace of albumin in urine - 1950 Joslin Clinic record -10 Moderate albumin in urine -13.5 Antibiotics 5.0 + “As measured in 1900 (Beeton and Pearson). These effects may be measurably less now, as environment is changing to produce greater differences between parents and progeny. Also, in 1900, it was a greater feat than now to live to be 80 or 90. ~9T- highest elevation of lipoproteins 6 ; ois 70% difference in distribution of lipoproteins, between 25% lowest and 5% highest, is equivalent bro9e - Taon to a total of 25 years in relative displacement of physiologic age.

Select target paragraph3