Boes . . . @eeos COLOR PLATES Plates 3.18 through 3.21 show fesions at 22 days post-exposure (Plates 8.18 through 3.20, Case 263 Plate $021, Case G3), : Plate 3.08 (XEO0O, H&E) Epidermas: Extensive trimsepidermial damage with leas involved zones on cither side, Loose iiminition of stratum corneum, stbsence of stratum granulosum, Parakeratinization with exfoliation of pigment containing cells, Disorgunization of Uhe malpighian layer. Dermis: Mild edema of pars papilliris with indistinet cupitlary loops. Moderately pronounced perivasculir cellular infiltrate (ymphocytes and mononuclear phagocytes), in superficial corium with mild tclangiectasis, Plate 3.19 (X100, H&E) Epidermis: Arcades of minimal damage occur in relation to excretory ducts of sweat glands. Stratum granulosum of good width and shows scant alteration. Under- 2 i £& i ron . . lying stratum malpighii shows marked decrease in pigment. In the deeper portion of the overlying, loosely laminated stratum corneum moderate amounts of pigment, however, are present. One narrow arcade of more severe transepidermal dumage shows alteration of the stratum granulosum with intercellular edma, pyknosis, swollen nuclei, and pigment scattered throughout, The latter is especiilly dense in the contiguous purakeratotic material. Dermis: A mod- y i t if erate cellular infiltrate, chiefly perivascular, is most pronounced in the superficial pars reticularis where there ts a mild telangiectasis. Transepidermal damage with disorganization of the mal]- pighian layer. Stratum granulosum absent. Malpighian and basul layer only two to three cells thick with exfoliation of pigment outward toward parakeratinized zone adjacent to stratum corneum, Pigment laden chromatophores and histiocytes in pars papillaris of corium. Latter is edematous and inffftrated by moderate numbers of lymphocytes, mononucicar phagocytes and scattered pigmented feukocyles. Capillary loops indistinet. Plate 3.21 (X100, H&E) (Case #63) ‘Transepidermal damage with disorganization of the malpighian layer. Slight parakeratosis. Migration or exfoliation outward of pigment. Loose lamination of stratum corneum. Pigment laden chromatophores and histiocytes in superficial pars papillaris of cortum. Marked cellular infiltration of pars papillaris. Slight telangiectasis of superficial pars reticularis. a ATSt mie pen mee pene Plate 3.20 (X400, H&E) (Case #26) a oe eee eee e “© eooe ee eee o 8 eee e e e . ee e #68 eo #00 @ oe . eee ooo e oe . oe oe e e ee oe ° 008 ee . e ° e «© nye ees een© 58