Serum Protein-Bound Iodine—Rall and Conard
886
This agrees fairly well with the figure of 76
ug. per day calculated independently from
urine and radioiodine studies and is compatible
with the clinical picture of a euthyroid status
despite an elevated PBI level and an increased
thyroid iodine secretion rate.
The depressed thyroidal iodine uptake rate
and renal excretion rate are puzzling and no
explanation for them is available at this time.
in serum proteih-hourr iodine (PBI) seems to be
general throughout the population since’ the
distribution curve of serum PBI is simple.
Column chromatography of the serum iodine
in twenty-five normal subjects in the United
States shows average values of iodoprotein of
0.8 wg. per cent and of thyroxine plus triiodothyronine of 3.8 we. per cent whereas in the
Marshallese the average iodoprotein level was
2.2 weg. per cent and thyroxine plus triiodothyronine 4.5 wg. per cent. The high iodoprotein levels appeared to account for the in-
crease in serum PBI in the Marshallese.
The
thyroidal iodide clearance and the renal iodide
clearance in the Marshallese were both depressed to approximately one half of normal.
The amountof iodine secreted by the thyroid
in the Marshallese was estimated to be 76
ug. per day.
3. Gatton, V. A. and Pittr-Rivers, R. A quantitative
method for the separation of thyroid hormones
and related compounds from serum and tissues
with an anion-exchange resin. Biochem. J., 72:
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method for determining thyroxine-binding capacity of serum protein. Arch. Biochem., 63: 461,
1956.
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computer program for the analysis of kinetic
data. Biophys. J., 2: 275, 1962.
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10. Stansury, J. B., BRowNELL, G, L., Ricas, D. 5.,
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Reprinted from the June issue of The American Journal of Medicine
volume 40, number 6, pages 883-886, copyright 1966 and printed in the U.S.A.
Published by The Reuben H. Donnelley Corporation, 466 Lexington Ave., New York 10017