Ic
iz
CLASSIFIED
Following the administration of the simulant by gavage, the initial
distribution of activity in the GI tract and in the tissues was very similar to that following inhalation exposure. It was found that the absorption across the GI tract proyided an important portal of entry for the
dry-~-particle simulant into the systemic circulation following an inhalation exposure. The compoajtion of the simulant material in the varioug
tissues during the first ¢ days following exposure appears to be dominated by one or a group of fisgion products, as seen from the similarity of
the radioactive decay rates: for most of the tissues, The results were
similar for both inhalation exposure and administration by gavage, Ex-
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dose received by the animals
esanes
ie dose to individual tissues was, with the
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UNGLASSIFIEL
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The internal ra
exception of the dose tothe:
he'thyroid, lower than the concomitant external
L
tissues.
Avot,
The thyroid received the:) ghest dose to any tissue from the internally
deposited fission products,‘fThe GI tract received the next highest dose
which was, however, less than 10 per cent of the dose to the thyroid.
The dose to the skeleton, while lowest in the 15-day period studied, will
probably be greater than thiat to other tissues over a longer period ‘of
time, since the skeletal: actjvity falls off more slowly than that in other
Sie theesee
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latter for the longer-lived{ssion products.
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ceptions to these findings were the thyroid and the skeletal tissues, the
former having anaffinity fox the short-lived iodine isotopes and the