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INTRODUCTION
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(Exposure to fallout from4 “puclear detonation) gr
¢ to an ‘aerosol formed
in controlled nuclear fissign, results ina biolo “ica}. hazard bath fFom)
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external radiation of the oaeand from radiation emanatinggem,
a dt
ternally deposited materia
revious studies, YFindicatedtt at the
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shortaterm effects which a gar following a cnaened exposure,(i,¢
external and internal expog
hive) result. primari. from the external|:Vata,
tion,
The amount of material ‘sufficiently great 9penetrate the.yna Lural i.
filtering defenses of the living organism and produce immediate effecth \
ig.pecessarily associated with a very large amaur
aeHye material,
There arg) however, situations
jation is of primary congern.
of externa fades
in whichthe|inyerhal
f
Such situat 9 fifclude the’ long-term 2:
effects p roduced by internally. deposited isotop¢
omwith long radiogstive”
. and. biological half-lives; long-term effects o Yetumulated small’ déses
of short-lived as well as long-lived isotopes; and damage to indivigual” i
tissues resulting from selective localization of isotopes,
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In order to assess these situations, it is necessary to understand
the
metabolism of the fission products, i,e., the uptake, distribution, and
retention in the body of the various isotopes which are inhaledand ine
gested, While a number of the long-lived fission products have been’
studied,'*
information is lacking in ve whiek first, on the metabolism
of a very early fission-product mixture (which includes
ortelived
fission products) and secondly, on the behave ettanec raedpaaray F
products competing in the beady metabolism withthe numerpuspinee
fission products found in the spectrum. formed on
p bombardmaaPor yranium,
The behavior of an isotope administered singly may differ frp,theisotope
taken ina mixture of fissionproducts,
4 we ao pes
While physical instrumentation can be used to. determine:‘the ‘external
dose to an organism, if is aot sufficient for calgulating the: ternal:expesure since complementary metabolic data aref‘lacking on‘the uantity’
of. internally deposited matexgial in particular Highyes and or Bans 4
and on
their turnover rates as a fugction of the amoun$pregent inco ete;Eyal
environment,
rr
ty ts
utehiney
In the present experimenter therclore, a direcp:gyaluation,; BS ty
of the uptake and “intribugen of fission products deposited in
nierna ly
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