DOCUMENT SOURCE Lawrence Berkeley Laboratory Archives and Records Office RECORDS SERIES TITLE Applied Science Divisian: Scientists’ Papers - Papers of William E. Siri ACCESSION NO. 434-91-0131 FILE CODE NO. 19-14-18 CARTON NO 7 FOLDER NAME COPY ACS by Dr. Leo Meyer (Marshall Island Natives) NOTES FOUND BY Perry Hall {2 UNIVERSITY OF CALIFORNIA DONNER LABORATORY AND DONNER PAVILION May 2 1963 BERKELEY 4, CALIFORNIA Dear Dr.Meyer, I received the pipet, the serum samples and the data on your subjects. I have distilled the serum, and when cur new scintillation counter is set up I will7the water sammoles and send you the results. + had all the water samples monitered in Donner Eab's whole body cgunter just to maxe sure they were not contaminated with Cr¢ As far as I can determine,Will hasrit done any work on the relationship between blood volume and lean body mass in the four years that I have worked for him. Nor can I find anything published by anyone at Donner Lab on this subject. The most recent article that I know of is by F.P.Muldowney of Harvard Med. School in"Techniques for measuring body composition" p 212. I enclose the title, page of this publication so you can look it up. Muldowney saves the linear regression of red cell mass(y) on lean body mass (x) as y= 32.74x Is this + 155.17 the formula that you are looking for? Dr. Eoward Parker the Associate Research Physician at Donner said that about 8 years ago, Will and others tried expressing plood volume in terms of og /em of lean vody wt. rather tnan cc/ gm of total body wt.Theoretic -ally this snould have sroduced a better correlation, but after trying a couple -fF hundred patients this way, the researchers decided to go back to “he old method.The €linic still uses the old methd. I will send you the water volumes, the Kgs o or fat and the lean body mass on your subjects as soon as possidle.I will also send you my calculations for your file. We were not able to establish radio contact as we nad hoped, so we have no news that is-nst in .the news~ caper, The mail service has also been very poor and we have had oniy one letter from Will.Al1l he said was that some of tne scientific equipment has broken down and this is spoil~ ing some of the planned research. ae Sincerely by } Rosemary Hughes P.S. Please forgive the typing..I'm no typist, and pecker. * 1 i - just a hunt