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UNCIASS IFIED
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4, Cellular changes
:
a. Range of sensitivity of cells
Ca
(list most sensitive - gonads - to least
sensitive - nerve, muscle, bone )
b. Relate sensitivity of nucleus to cytoplasm
5. Effects on the whole organism
a. Range of survival dose on mammals (guinea
pigs 200 r, rabbits 800 r)
:
So
b. Compare with non-mammalian radiation
(virus, for instance, 1,000,000 r)
Sars S
(1) Point out species variation and
ae
’
position of man
6, Clinical syndrome in man (nausea and vomiting,
oo
ae Special piace of hematopoietic response
to radiation
b. Delayed effects
(1) Reduced longevity
(a) reduction in life expectancy validity of concept at low
levels of radiation
(2) Production of leukemia and neoplasms
(tumors )
G. Relationships of damage mechanisms to dosages
1. Aplastic anemia, leukemia, and cancer as a
result of exposure to radiation
a. Doses at which observable damage occurs;
relationship of probability of damage to
dose and dose rate; latent periods; doubling
doses;
relationship to tissue irradiated
b. Relative importance of cancer and leukemia
under various conditions:
external sources;
exposure of various critical organs to
radiation from external and internal sources:
dungs,
fo
:
hematopoietic depression, epilation, bleeding, etc). .
gut, thyroid,
- 18 -
skeleton, etc.