Jn Figs bo otue fre queucy dustrinunon of G-atnine
msebussty atl egerepon fee the Rongetapes:
presente Asieutlar listecrie ¢
wwe York (1
Mite peeratien ds dhigudend or ow perariye pore
poses
The tWo Gisthitediens ate essentials come
PeeTuOb ars Lo Ghee Ate hes ated al st per peeea
exhibn prnedablys
wihothe arc roede ue the meh
bourhood of P75 Tobias thi poms as the div rue,
freageen dual
Pole. @peret es. Ts Gat ifudten
thet mearle OFopr cent ofthe Ronceapese ar hin
eseretors
A breakdown of this pee dation mts
exposed and unexposed grouns shows almust identical
Mean S-anmano-wohwavymIe ae. Ex retiot Values for
the two categories vexposed 2-07 = 0-06 and unexsposet Ph ed
A seater plot between ca ssun -
137 Jovets and S-arnne-sebutytic aridacvel shows no
corpelatie. Fie. 20 ant @ simnlar pict between
PARC bevels atkd
Lane sob tie Aa SOW Ss He
eorrebit ad
eye pet
"
Varin at
hg
:
“eat ee
i
dees fete aeacd
Viper gos tas
we
“
WO
woges
be
1
ys here
tore not exposed ty significant radiauion. Was 2-2) BUS wt oad,
Ate
7
i
siaeanthy
tho
Velie
ey tetate,
caterent
froth. the
prevalence ia tas
Rongelap group. A number of families are inchided
inthe Rangelan data 'that is. father. mother and at
Jeget one eh Di amb
Pat evevet btu t
of ces
oe
be the ol
hard
ex reten div
aes Wath stent
tant gebe tic antermuation.
There were 2b such
Matitete witha tetated oeoffprimg 28 posh excretore
and 2 jow «Nereters. Une ut the fow excretor off.
spring Was Wegitimate. as determined by bload group
data, leaving one unexplainable exception to genetic
hypothesis.
Rubini et al§ have recently demonstrated that
8-amino-isobutvrie acid exeretion can be a sensitive
indicator of radiation exposure. The mechanisns
involved is probably the same as that underlying the
effect of nitrogen mustard on f-amino-‘sobutyric
acid excretion’.
Such agents markedly increase
breakdown of deoxstribonucleic acid: the thymine
thus released is effectively converted to %-aminoqebutytie acid in man?® and excreted into the urine
since no appreciable tubular re-absorptionof @-aminoisobutyrie acid occurs’, Tt is unlikely that the high
prevalence of high-level §-amino-isobutytric acid
excretors found in Rongelap is due to radiation. The
identical average 8-amino-isobutyric acid valuesin the
exposed and unexposed group precludes the possibility
that the elevation is due to the fallout exposure in
4