,
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showing minimum count at 4th- 8th week.
5 cases revealed a count
of less than 2,000/mm°, 13 less than 3,000 and 5 less than 4,000.
In one case, the leukocyte level depressed to 800.
A correlation
was found between these minimum count and the externally irradiated
gamma doses of each individual.
At first lymphopenia was noticed
and then neutropenia became marked.
proved.
Since 8th week recovery was
In many cases remarkable eosinophilia was observed at
that time.
In some cases immature neutrophils appeared in peripheral
blood slightly.
b.
Erythrocytes : In severe cases slight anemia was observed,
' accompanied by the depression of reticulocytes.
were higher than 1.0.
Color indices
The Price-Jones curves of erythrocytes
diameter were displaced to the right of normal one at first, which
returned to almost normal after one year.
c.
Platelets : Platelets counts showed increasing depression,
reaching minimum at the 4th- 7th week ( 15,000 - 100,000/mm°).
Slight eoagulation disturbances observed in a few cases.
d.
Bone marrow: In severe cases bone marrow was highly
hypoplastic at the critical stage, which changed to hypoplastic and
turned into almost normoplastic.
after a year.
Recovery was not complete even
At the recovery stage coexistence of hypoplastic area
and hyperplastic area was observed in histological sections.
e.
Morphological abnormalities : Several morphological
abnormalities, e.g. abnormal granules in lymphocytes or neutrophils,
vacuoles in various leukocytes and megakaryocytes, giant nuclei and
hypersegmentation of neutrophils, binuclear lymphocytes, abnormal
mitosis of erythroblasts etc. were observed for about one year,
especially at the critical and recovery stage.
A little increase of
"mitotically connected abnormalities'' was found in bone marrow
smears of a few cases after 10 years.
f.
Recovery: The cumulative distribution curves of numbers of
leukocytes, erythrocytes and platelets displaced to the left of normal
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91
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