- 15 cell crigin and that C-cell neoplasms were not readily induced by
The solid lesions were very infrequent in controls of the same age
Radioimmmoassays
for
tran animals which had been
issue because the titre was quite variable from animal to animal
of interfollicular cell hyperplasia (found in rats) varied from
many of which did not have a demonstrable solid cellular tumor.
Wi
to Dr. Hunter Heath of the Mayo Clinic for carrying out sample ass
tonin for us.
Dr. E.D. Williams of the University of Wales, Ca
are grateful
of rat calci, being an author
on the medullary carcinona of man and the interfollicular ceil les; ons of rats, was
called upon for assistance in the identification of the C-cell les: ons.
He has point
out to us by direct personal assistance the characteristic feature: of these lesions
while reviewing many microscopic examples. The features are rather ¢asily recognized.
Since the interfollicular cells normally lie between the foll: cles, their proliferation, as in hyperplasia of such cells, tends to spread the ft llicles apart.
A neoplasm arising from such cells not only expands the interfollic lilar space in a
local area, but appears to completely surround an occasional norm’ follicle.
The
expanding neoplasm becames lobulated with thin commective tissue margins and septae
around the clusters of proliferating cells, a feature which Willia is has appropriate!
called "packeting"’.
Normal follicles often aretrapped in these 7 rowing lobules.
Fortunately our procedure of double labeling with 13Li
and SH-TaR Pith radioautograpt
has not only shown increased mitotic activity in such spreading les ions, but has alsc
distinguished a trapped notmal follicle (because of
131
I uptake in it) fram the tiny
follicles sometimes seen in the undifferentiated solidcellular les: lions with an occasional primative follicle which does not pick up iodine.
The uncertainty of distinguishing C-cell neoplasms fram other solid cellular
lesions prampted us to hold up publication describing the high inc: dence
following low doses of
131,
of neoplasms
This was the first of a series of 35 anuscripts submitt