416
PRENTICE}! BIRE;“BERLIN, WYDE; PARSONS, JOINER, AND LAWRENCE
7
3
2 TaN:
PRIVACY ACT MATERIAL REMOVED
bean, betes Ege? A Ve°TABLE IV
D
?
mo
| Petlent
9 getektogdapsonewtoht wanfaders
ews
Mu
47
20
38
Mean
ics
:
op
Moe
FF
oF
Diagnose -
TE Gey
P+ Ob.
1, 60.8
+ sais
49.8
$7.8
“28.0
43.0
|.
610
H-CVv.D.
(61.0
H.C.V.D, with uremia
629.6. fo 49.0
29.8 |” 546
32.6
|
ASH.D.
H.C.V.D.
S64
{st 5.8
B. With peripheral edema
48
FO
71
62
74
|
“
$9.6
73.4
F
“T8.5
61.
FG]: 69.4;
“4.
| F
47
Mean
“468
M
mM
40%:
55.5:
M:
FC
‘
ry
|
-
26:5
$6.6
27.6|
35.2
340.
49.0,
* §3.2":
65.0 -
' 33.6°
44.0
70.0%.
, 417
63.7 -
3M
$6.75
$3.51
36.9
:
564
60.0
59.$
66.5
$6.0
°
Rheum. he, disease
[AS.H:D.
H.C.V.D.
H.GV.D.(very obese; little
.
Rh. ht. disease
|H.CV.D.
{|H.CV.D
210.6
C With pulmonarycongestion but no peripheral edema
$9
74
uM
53
Mean
F
M
F
F
$5
82.0
-102.3
$1.7
614
74.4
M4
35.4
35,2 ©
27.5
42.0
44.6
68.0
4.8
33.1
47.4
A.S.H.D. Emphysema
M
ial infarct.
| H.CN.D,
H.C.V.D.
14.3
Pace, Kline, Schachman, and Harfenist (10)* and
0.27 is the fraction of solids in wet tissue. The
carcass weight was taken as 56.5% after subtracting bone minerals.
Inserting these values in the
formula above,the total body water one would ex-
pect to observe with tritium is then approximately
74.5% of the lean body mass. The correction
.factor representing the maximum error, f.¢., for a
lean subject, is 0.73/0.745 = 0.98. The difference
of about 2% correspondsclosely with the average
of 2.3% in the differences in body water volumes
observed when antipyrine is compared with tritium,
as may be seen in Table II. This correction is not
made in Tables II-V, because its exact value de® The value used here is derived from Pace's figures
for the nitrogen content of dry, fatfree tissue.
3012068
pends upon a more exact determination of lean
tissue mass in individual cases.
Twofacts are worthy of note. First, the magnitude of the error is not changed by the degree of
obesity; and second, in edematous states, the er-
ror decreases as edema increases. The first is true
because adipose tissue does not alter significantly
either the amount of exchangeable hydrogen atoms
or the volume of body water. The secondis evi-
dent because as body water increases, the amount
of tritium exchanged remains the same.
DISCUSSION
Radiation dosage is always an important consideration in the utilization of radioactive tracers.
Two me. of T,O were selected for use in these
PRIVACY ACT MATERIAL REMOVED