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DOCUMENT SOURCE
University of California at Berkeley
The Bancroft -Library/The University Archives, Berkeley CA
RECORDS SERIES TITLE
Kenneth
Garden
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Lagaers
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WENNESLAND, BROWN, HOPPER, HODGES, GUTTENTAG, SCOTT, TUCKER. BRADLEY
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Fic. 4. Vrac of 201 Heartay Men ix Rezation to Bopy Sunract Aaga as CaLcu‘LaTep From Dy Bors’ Formuta
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The linear regression Equation 4.4Table II) describes the data. Arrows point to
two subjects whose weight: height rauos were exceptionally high and whoappear
to the far right of the population scatter shown in Figures | and 2. Data-_relating
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to these two subjects are marked by ¢ in Table I.
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JOLLE LEY
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FOUND BY/DATE FOUNO
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Helga
tube (33) and that Vwb and Vpl may be lifger
workers (5) found that regression to.eigh
«
observed values only systematically. Correction
factors which apply to data on healthy subjects
mi. at most by substitution of height for (height )*
in the equation of Allen and co-workers (5) over
the range of heights encountered by these authors €+.57 to 1.89 M.}.
than they appear when calculated from Vrbe and a ~and-weight gave the most adequate .expressionzof
large vessel hematocrit (29, 30). Application of -sheir own and other published data. ¢ Howeetr.
correction factors such as are used widely at pres- ‘the function, (height)*, is dearly linegx Over the
ent, 0.96 for trapping (34) and 0.91 for body :_ narrowrange of heights endountered amongadult
venous hematocrit ratio (31), would change the men. ~The predicted Vwb ts “alfered Sony: 28
do not necessarily apply to subjects with disease. Plasma trapping varies with the hematocrit level (35) and the body: venous hematocrit
ratio is altered in some circulatory disorders (11,
35), with splenomegaly (36) and in pregnancy
(37). Other investigators may conveniently com-
pare their data with ours before they apply any
desired correction factors.
Wrbe as determined
here is independent of the body: venous hematocrit ratio. but Vp! and Vwb are not. It should
LF5
be noted that Vrbe as reported here includes leukocytes and platelets because hematocrits were
read to the top of the buffy coat.
The finding that blood volume relates more
The regression-equations presented here should
not be relied..cn—for heights and weights outside
the range covered by our observations, since
there is no reasomrto suppose that the regression
planes wouldcontinue-to-be the same beyond the
observed domain. ‘Furthermore, the accuracy
with which the planes are estimated decreases as
we depart from the ceriter {indicated by a cross)
of the height: weight seater diagram (Figure 1).
For predicting ‘‘normal” volumes in individual
cases, the graphic representation of the regression
closely to one or another combination of height
planes shown in Figure 1 has several advantages :
a) No calculations are required; 6) one can see at
(1-6, 13, 14). von Porat (4) proposed the use
weight are within the range covered by our calculations; and ¢) any existing peculiarities of
and weight than to either measure alone is im accord with the results of several other studies
a glance whether the individual's height and
of (height)* as a reference and Allen and co-
height: weight relations of the individual under