162
s.-A. KILLMANN AND OTHERS
5- 539-59
FIG. 6
POSSIBLE EFFECTS OF VARIOUS TYPES OF THERAPY ON THE
DOSE-MORTALITY CURVE IN DOGS EXPOSED TO X-RAYS
400
75
= Homologous =:
=
marrow
= transplont
Homologous
2
marrow
=:
transplant
=
successful
“unlikely to be=:
an
So
Mortality
Without
therapy
=
25
successful
possibly
and
antibioti
0
200
400
Dose inr
600
800
1000
KO 1203
Reproduced, by permission, from Sorensen et al. (1960)
transfusions were required to fill the platelet production gap. The last
transfusion was usually given on day 22, 23 or 24. The difference in
survival—1 out of 10 dogs in the control group versus 8 out of 10 in the
treatment group—clearly indicates the efficacy of functional replacement
therapy at the dose level investigated.
Similar treatment programmes have
been tried at higher levels of exposure, but so far no significant benefit has
been observed when the dose was 500 r or more (see table on preceding
page).
|
The effects of functional replacement therapy are summarized in Fig. 6.
In essence the treatment employed shifts the LDs9 of dogs from approximately 275 r to about 450 r. At the same time the dose-mortality curve
becomes steeper than in untreated animals. Functional replacement
therapy does not seem to be of particular value beyond 500 r.
Cell trans-
plantation, on the other hand, seems to be successful only at higher doses