made. In this group also, the administration of very large doses of I 131 was warranted.”
(pp. 37-38)
Results on Patients, p. 41: no discernable results in most cases.
January-March, 1948:
Hematological Effects of Total Body Irradiation from External andInternal
Sources/B.V.A. Low-Beer (R.S. Stone in charge, Project 48C) Objectives are same as
those reported above. "The present report deals with the hematological changes observed
in patients treated for arthritis with radioactive phosphorus administered intravenously.”
21 patients were so treated; 4 men, 17 women, between 16 to 67yrs old. (p. 41)
Metabolism & Effects of Radio-lodine (I131)/Earl R. Miller: "From January | to March
31, 1948, 140 millicuries of [131 was received each month and was administered to 34
patients as follows: Tracer doses only (250 microcuries orless) ... 16, Test doses (up to
2000 microcuries per dose)... 5; Tracer and therapeutic doses ... 12; Therapeutic doses
alone ... 1" (p. 46)
April-June, 1948:
Metabolism & Effects of Radio-Iodine (I}31)/kar! R. Miller: tables with patientinitials,
date of injections, dose levels, and percent uptake; descriptions of someofthe patients.
3 patients with carcinoma of the thyroid were given high doses of radioiodine; within two
months, they had developed myxedema. (pp. 42-43)
July-September, 1948:
The Metabolic Properties of Plutonium and Allied Materials/J.G. Hamilton, Project
48A-I: Tracer Studies/Arsenic: "The site of deposition of arsenic in the red blood cells
has been investigated. the major part of the arsenic is combined with the globin fraction
of the hemoglobin o the red cell and this increases with the addition of arsenic carrier.
These studies are being continued in order to determine if the samesituation exists in the
human asin the rat, since this method of labeling a red cell when combined with the
radioautographic technique should enableone to determinethelife o the red cell in the
body in normal and abnormal conditions.” (p. 5)
Biological Effects of Radiations From External and Internal Sources/R.S. Stone, Project
48C: Statement of the Program. *...the Arthritic Clinic of the University of California
Hospital, composed of physicians from the Medical, Orthopedic and Radiological
Divisions, became interested some years agoin the effects of total body irradiation on
chronic arthritics, particularly those with ankylosing spondylitis. Such patients are
therefore selected for this type of treatment by physicians having no connection whatever
with the Atomic Energy Commission,and their treatment and follow-upis given by
physicians in their capacities as membersofthe staff of the University of California.
Project 48C, a hospital portion of the Radiation Laboratory, has taken advantage of the
fact that these patients were being treated in this mannerto study the effects of total body
irradiation on the blood.
From the inception of the program in 1942 until October 1946, the patients were
treated by exposure of their whole bodiesto x-rays of various energies from 100 to 1000
kv. Starting in December 1946 radiophosphorus wasused as the source ofradiation,
being given intravenously, and it has been used exclusively since that time. the last
patientto be treated in this group received her final treatment on May 24, 1948." (p. 32)
Lawrence Berkeley Laboratory
Archives and Records Office
Human Radiation Experiments Search and Retrieval Project
Anna Berge Research Notes
Electronic DocumentTitle: Quarterlies
Apmnil 4, 1994
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