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administration of EDTA on calcium blood levels, but lots on EDTA andits compounds
on calcium blood level [almost sic] (May 21, 53)
A project report dated October 52-June 53 summarizes a study of two general techniques
of labeling plasma proteins compared in a number of normal individuals. Thefirst
involved the simultaneous administration of 1131 tagged albumin to determine turnover
pattern of exageneously labeled protein moiety, and the second involved the
administration of $35 labeled cystine or methionine following incorporation and
disappearance of $35 labeled albumin and globulin.
Project proposals of 1953 include descriptions of astatine studies, studies of the
radiological effectiveness of injury produced by alpha-particles and beta-particles, and
the effects of heavy nuclei in biological systems.
1954-1955
Hamilton took human thyroid slides from patients given tracer amounts of At211; two
had thyroid carcinoma, the other 6 ha d different types of non-malignant, fibrotic tumors
(letter to Hermann Lisco on March 25, 55). He had been doing studiesat least since 1954
to see if he could treat hyperthyroidism and carcinomaofthe thyroid gland.
1956
references to cases of skin-contamination from Pu at Hanford (Feb 3, 56, from
_ at Hanford to
), and to Na22 experiments on humans(Feb 6, 56, from Harold
Elnick of the Veterans Administrative Hospital).
Carton 8
In 1936, Hamilton and Dr. Stone conducted studies of 3 leukemia patients and NA24. In
1937, he studied radioiodine and thyroid disorders; this was continued during the war by
Dr. Soley and Dr. Miller. In 1938, he studied the rates of absorption of radioactive
isotopes of sodium, potassium,chlorine, bromine, and iodine in normal human subjects.
His bibliography should have moreofthis information. (In 1956, Aebersold requested
information on whenthefirst tests on humanswere with irradiation atht he cyclotron,
with isotopes Na24, p32, and 1130. Isotopes in medicine were used at Berkeley, Chicago,
Michigan, and Boston. Low-Beer and Erf did studies of phosphorusat Berkeley.
Aebersold then wrote a history of this called "Development of Nuclear Medicine”.)
Jan. 28, 1948, Hamilton sent Wensel a summary of OSRD contracts he worked under.
These include:
NDRC-8 OEMsr-456 (Feb 1, 1942 to Aug 31, 1944) Hamilton and Axelrod
studied mustard gas and Levisite (7)
NDRC-9 OEMsr-196 (June 1, 1942 to Dec 31, 1944) Hamilton and J. Lawrence
NDRC-12 OEMsr-799 #9938 (Oct 1, 1942 to Apr 30, 1943) Scott, Axelrod,
Copp,Fisher, Crowley, etc; this project became NDP-48-A-1
NDRC-Research E-54 (Nov 1, 1942-Apr 30, 1943) Hamilton and Chaikoff (?)
(strontium?)
Lawrence Berkeley Laboratory
Archives and Records Office
Human Radiation Expenments Search and Retrieval Project
Anna Berge Research Notes
Electronic DocumentTitle: Bancroft/EOL
April 4, 1994
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