Hematological Effects of Total Body Irradiation from External and Internal
Sources/B.V.A. Low-Beer: report on patients treated with S-ray and radiophosphorus.
P32 obtained from Oak Ridge. 5 patients treated for arthritis, only one showed
improvement, and one actually showed worsening; they will continue studies. (pp. 34-35)
Metabolism and Effects of Radio-Iodine (I131)/Earl R Miller: "In several patients with
carcinoma ofthe thyroid, destruction of the thyroid has been achieved by radioiodinein
doses on the order of 60 microcuries. Clinical and chemical myxedema has been
produced. Destruction of the thyroid was carried out in order to see if the metastases
would concentrate iodine when the normal thyroid ceased functioning. So far no success
has been attained with this group of patients, most of whom has anaplastic growths.
Studies are being continued onthis.” (p. 37)
Biological Studies of Radiation Effects/J.H. Lawrence, Project 48A-II Blood
Coagulation in Polycythemia and Leukemia; Relation of Heparin and Platelets;
Quantitative Measure of Clot Retraction and Heparin Clotting Time/Robert L. Rosenthal.
A study of blood coagulation on 45 patients with polycythemia vera, 28 patients with
leukemia, and 16 patients with other diseases. (p. 25)
Biological Effects of Radiation from External and Internal Sources/Robert s. Stone,
Project 48C Hematological Effects of Total Body Irradiation/B.V.A. Low-Beer. "This
report is concerned with hematological effects of radioiodine (I!3!) on patients. Two
groupsof patients have been observed. In one group,including eight individuals, seven
had Graves' disease and one had chronic thyroiditis. A second group ofeight individuals
had carcinomaofthe thyroid. Observations were made over periods from three months
to one and a half years. Carrier-free 113! was administered orally. The doses varied from
“test” doses to therapeutic doses, All total doses were given in multiple fractions of
different size at different intervals. In the tables the individual doses are shown and the
time of administration is given. Clinical management and radioiodine treatment of these
patients including uptake and excretion studies are being carried on by Dr. Earl R.
Miller.” (p. 65)
1950 Publication:
Studies in Glycine 2-C 14 Metabolism in Man 1/ The Pulmonary Excretion of C !402/N.L
Berlin, B.M.Tolbert, and J.H. Lawrence Sept. 1, 1950: concern about use of Carbon14 in humanssince it has such a long half-life; but animal experiments show mostofit is
excreted soon after intravenousinjection. This study measured rate of pulmonary
excretion of Carbon-14 as a C!4Q2 when administered as glycine-2-C!4 to four patients.
Worksupported in part by AEC. "The lack of hazard involved in the use of Carbon 14 in
the manner described is discussed from the standpoints of excretion and possible
retention in chemical compounds having a long turnover time.” (p. 6)
October-December 1949:
Biological Studies of Radiation Effects/J.H.Lawrence, Project 48A-I Plasma and Red
Cell Iron Turnover Studies in Normal Subjects and in Patients having Various
Hematopoietic Disorders/R.L. Huff, T.G. Hennessey, R.E. Austin, J.F. Garcia, B.M.
Roberts, J.H. Lawrence: "Iron tagged with iron 59 was injected intravenously into
normal human subjects and patients having the following disorders: polycythemia vera,
secondary polycythemia, lymphatic leukemia, myelogenous leukemia, pernicious animia
Lawrence Berkeley Laboratory
Archives and Records Office
Human Radiation Experiments Search and Retrieval Project
Anna Berge Research Notes
Electronic DocumentTitle: Quarterlies
April 4, 1994
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