: : . . gift Dr. Bair from a paper given by them last October (Sanders, C.L., 1970). ‘ ides He I i . sat waidt Rair and his colleagues have done the most relevant plutonium oxide inhalation cxperiments. 4 42iah, "Nonunifoerm irradiation cf the lung from deposited radioactive particulates is clearly more carcinogenic than uniform expo- vrae beta-irradiation. + . sure (on a toial-lung dose basis), and alpha-irradiation is more carcino- genic " The dceses required for a subciantial tumor incidence, are very high, however, if measured in proximity to the par- « a dose-effect curve. . . a:d, again, there are no data to establish the low-incidence end of e And there is no general theory, or data on whichto . ticle; oe BIN! NETO MWR DE NSTGEOS SRSTAaOROO base a theory, which would permit extrapolation of the high incidence portion of the curve into the low incidence region." | agree and J suggest - < shee SpeFESS om vowechoreremanence. rewtmnmnanna seerorunaror FEbetEG that in sich a circumstance it is appropriate to view the standards with extreme caution. ° “ There is another hazardous aspect of the particulate problem in In case of an aerosol depositing on a surface, the material may be resuspended in the air. This process is wih which suostantial uncertainty exists. crudely described by a quantity called a reeuspension factor which is re- ok ~ problem is to say there is some evidence that plutonium particles become attached to larger particles and are thercforz no longer potential acrdsols. Unfortunately there is also evidence that large particles generate acro- eoatite turbulence, and are heace blown abont more readily, snhan Aa “f mem SPE OR, CAE Th STOPS SEITAO better than this for plutonium oxide, but the handiest way to dispatch the wwe owen ope, Undoubtedly it can be pinpointed somewhat @ markable in that it seéms generally known only to within a factor of bil- lions (Kathren, R.L. .1968). o ig! POF we 18M comme ! op 1 “3 wot th et , , 1-162 FOF BaPARFee ee HO 6: Re Seb ome oo ead A terdBd CBeeAinaeatclad Cent9 theFLEDeULDE WheWall AAA BTEN bale Piha Alil AM ane Mitre telRael NetcRd tlh mab salicari rer teanaid aI Ny stighe thie desi Pant, City heen re tt Ae Cees meee os ore me seam os ew eeee oe ee meee tem fe er ewe sees eee ee one . ee eS ak mete meet © we ee ee ee ee re on + tee C: :