APPEIDIX "3" ATPEMDIX 3,2.3-1.3 3.2232 the patholopical changes in the skin,this will suffice,..nmore complicated studics of the local lesion, such as bietoriologics: and chcemical observations can be deferred for lebvoratory investigation if one knows that the lesion produced in the lab is the same as thet produced in the field..... "It is possible that satisfactory studics (i.c, of mortality) ean te mde ina poriphcral zono (commrable to 1.5 - 2.5 Nm at Hiroshima) where these conpliecation (i,c. blast an@ radintion offeets) Will be minimized, "A study of all the systemic pathological and chemicel changes from burns would require equipment too claborate for ficld use. If only the essential observations of urinc, blood counts, feratocrit and plasma protcins are madc, then these ean be uscd as a check against more dctailed studics....in the laborntory. "The pig is the best test animal, next best and should be uscd, Rats and euinca pigs are The pigs skin is more mearly like human sitin then any other eanimels....It cppeoars neccsesry to devise suitable shcltors....that will shelo the animal but not shicld hin fron thermal rvdiations of the bomb...It...(is).... dusirsble to have all tost aninls eeclimted for a chort tine before tests ore rade,.,..snall pics arc ensi r to hendlce than large ones." University of Rochcstur Lettcr of Henry A. Bleir

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