Table 2.
Substitution frequency of isoleucine for other amina acids
in the separated a and g chains of human hemoqlobin.
Substitution frequency (Xx 107°)
ample
rxposure
Globin?
Pre-a
a
Pre-g
B
Expected value”
8A
69 R
12.93
7.61
2.35
40.36
12.42
15.71
Z24R
175 R
13.45
4.27
1.25
59.42
7.12
13.93
35R
175 R
5.19
c
4.34
c
8.32
6.33
71R
175 R
8.29
C
5.27
c
13.54
9.41
836
OR
2.45
Cc
2.05
c
4.4)
3.23
8670
OR
2.12
1.75
1.99
10.81
3.40
4.53
868)
OR
4.35
5.57
1.76
8.69
5.04
4,34
“values reported in Table 1.
Values expected when the Pp percertace
G of each fraction and its substitution
frequency are considered in the total.
Ae om
“The substitution frequency in this fraction was not determined; the quantity
of polypeptide in this fraction represented less than 55 of total.