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9$-21-1994 12:12
5162825311
BNL~MED. DEPT.
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2
P. O04
of injury and the clinical manifestations are rroportionate to theldose.
is particularly true of the symircmes of whole body radiation.
I repeat, highly dependent on dose and time after exposure.
description.
This
mo latter is and
There}is no simple
The problem is subtle and complex am one must alwaya bear dose and
time in mim.
THE SYNDROMES FRCM TOTAL BODY PENETRATING RADIATIONS
The dose dependent symiromes resulting from total bedy expoeurt in the
mammal have been described in detail and I shall only aimmarize them
here.
further details one is referred to the following references (1-12
).
large doses (approximetely 6000 r or more) the central nervous syst
wich can be aboreviated CNS is produced.
being irradinted or after some hours.
Death may occur under th
For
After
8y ndrome
beam while
*he clinical pieture is chardcterized by
nyperexcitabi lity, disorders of eguilitrium, incoordination, respiratery distress
and intermittent stupor.
Convulsions may preceed death,
this syndrome are always uniformly fatal.
Doses capaple of producing
If an oceasional snimal,
Bnd presumably
Man, survives this CNS he has yet to experience the gastrointestinal] syndrome (GIS),
which when produced by doses in excess of 1500 r is always fatal within three to
nine days for mammals.
laboratory animals,
Presumably man also will respond in a compargble manner us
The GIS is so named because of the tarked nauseq, vomiting,
diarrhea, and denudation of the lining of the small bowel,
fatal syndrome in most laboratory animals,
The GIS
If the short duration GIG
Hs a uniformly
cf a few hours
resulting from lower doses, does not produce the three to nine day depth, the sur~
vivors of this syndrome have yet to experience the sequelae of bone
which has been termed the hemopoietic eyndrome (HS).
mhrrow depression
The HS is not npcessarily fatal.
It is the clinical nicture that 1s seen in the lethal range for all
ls and in
general the 50% lethal dose valuee reported, represent the 1D°9 for tHe sequela of
hemopoietic depression ~ namely granulocytopenia, depressed defenses
tier, thrombopenia, and anemia with the possible resulting infections
against infec4iffuse pur~ |